Evidence map›Paper›PMID 18234097›Full record

ArticleGenome biology2008

Quantitative methods for genome-scale analysis of in situ hybridization and correlation with microarray data.

Chang-Kyu Lee, Susan M Sunkin, Chihchau Kuan, Carol L Thompson, Sayan Pathak, Lydia Ng, Chris Lau, Shanna Fischer, Marty Mortrud, Cliff Slaughterbeck and 3 more

Abstract readComparative Study
In one paragraph

Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. A transcriptional signature of hub connectivity in the mouse connectome.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  4. Article
  5. Cell-type-based model explaining coexpression patterns of genes in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chang-Kyu LeeAllen Institute for Brain Science, Seattle, WA 98103, USA.
Susan M Sunkin
Chihchau Kuan
Carol L Thompson
Sayan Pathak
Lydia Ng
Chris Lau
Shanna Fischer
Marty Mortrud
Cliff Slaughterbeck
Allan Jones
Ed Lein
Michael Hawrylycz

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the emergence of genome-wide colorimetric in situ hybridization (ISH) data sets such as the Allen Brain Atlas, it is important to understand the relationship between this gene expression modality and those derived from more quantitative based technologies. This study introduces a novel method for standardized relative quantification of colorimetric ISH signal that enables a large-scale cross-platform expression level comparison of ISH with two publicly available microarray brain data sources.

Indexed as

In Situ HybridizationOligonucleotide Array Sequence AnalysisAnimalsBrain ChemistryColorimetryGene Expression ProfilingGenomicsMiceMice, Inbred C57BL

Identifiers

PMID18234097
PMCPMC2395252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.