ArticleJournal of clinical biochemistry and nutrition2008
Dynamic aspect of reactive oxygen and nitric oxide in oral cavity.
Article in Journal of clinical biochemistry and nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- «Salivaomics» of Different Molecular Biological Subtypes of Breast Cancer.Current issues in molecular biology · 2022Article
- Tolerance of Rodents to an Intravenous Bolus Injection of Sodium Nitrate in a High Concentration.Biology · 2022Article
- Relationships Between Oral Microecosystem and Respiratory Diseases.Frontiers in molecular biosciences · 2021Review
- Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives.Diagnostics (Basel, Switzerland) · 2020Article
- Printed Organic Transistor-based Biosensors for Non-invasive Sweat Analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Article
- Investigation of Polyurethane Matrix Membranes for Salivary Nitrate ISFETs to Prevent the Drift.Sensors (Basel, Switzerland) · 2019Article
- Assessment of dental caries and salivary nitric oxide levels in children with dyspepsia.BMC oral health · 2019Article
- HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation.Frontiers in immunology · 2017Review
- Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer.Diagnostics (Basel, Switzerland) · 2016Article
- Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena.Toxicology in vitro : an international journal published in association with BIBRA · 2016Article
- Salivary lipid peroxidation and total sialic acid levels in smokers and smokeless tobacco users as Maraş powder.Mediators of inflammation · 2012Article
- Role of hydrogen generation by Klebsiella pneumoniae in the oral cavity.Journal of microbiology (Seoul, Korea) · 2010Article
- Regulation of nitric oxide production in health and disease.Current opinion in clinical nutrition and metabolic care · 2010Review
- Effect of Nitric Oxide on the Oxygen Metabolism and Growth of E. faecalis.Journal of clinical biochemistry and nutrition · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral mucosa is a critical protective interface between external and internal environments. Therefore, it must serve as a barrier to a huge number of microbial species present in the environment. Saliva is an important factor that provides for the environment in the oral cavity, and it is indispensable to the host defense reaction in this manner. Oral neutrophils are also important contributors to maintaining the balance between health and disease in this complex environment. These produce reactive oxygen species, nitric oxide, and several antimicrobial peptides, and enzymes. Neutrophils and saliva all contribute to the maintaining the health of the oral cavity in overlapping but independent ways. In addition to production by neutrophils and macrophage, some bacteria can also generate superoxide, hydrogen peroxide, and nitric oxide. Dietary intake of nitrate-enriched vegetables might play important roles in the protection of the oral and stomach against hazardous pathogens via the gastro-intestinal-salivary cycle of nitric oxide (NO) and related metabolites. This review will focus on defense system of the human oral cavity and metabolism of reactive oxygen and NO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.