ArticlePloS one2008
Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cells.Frontiers in immunology · 2026Article
- EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity.Cell stem cell · 2022Article
- Induced Pluripotent Stem Cell (iPSC)-Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and Challenges.Current hematologic malignancy reports · 2019Review
- Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro.Nature biotechnology · 2017Article
- The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Programmed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- New cell sources for T cell engineering and adoptive immunotherapy.Cell stem cell · 2015Review
- Re-adapting T cells for cancer therapy: from mouse models to clinical trials.Immunological reviews · 2014Review
- Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy.Nature biotechnology · 2013Article
- Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.The Journal of experimental medicine · 2013Article
- Article
- Unusual selection and peripheral homeostasis for immunoregulatory CD4(-) CD8(-) T cells.Immunology · 2013Article
- T-cell tolerance: central and peripheral.Cold Spring Harbor perspectives in biology · 2012Article
- Thymic negative selection is functional in NOD mice.The Journal of experimental medicine · 2012Article
- Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte.European journal of immunology · 2012Article
- αβ versus γδ fate choice: counting the T-cell lineages at the branch point.Immunological reviews · 2010Review
- gammadeltaTCR ligands and lineage commitment.Seminars in immunology · 2010Review
- Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint.Current opinion in immunology · 2010Review
- Article
- Checkpoints in lymphocyte development and autoimmune disease.Nature immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe binding of the T cell receptor (TCR) to major histocompatibility complex (MHC) molecules in the thymus determines fates of TCRalphabeta lymphocytes that subsequently home to secondary lymphoid tissue. TCR transgenic models have been used to study thymic selection and lineage commitment. Most TCR transgenic mice express the rearranged TCRalphabeta prematurely at the double negative stage and abnormal TCRalphabeta populations of T cells that are not easily detected in non-transgenic mice have been found in secondary lymphoid tissue of TCR transgenic mice. METHODOLOGY AND PRINCIPAL
findingsTo determine developmental pathways of TCR-transgenic thymocytes, we used Cre-LoxP-mediated fate mapping and show here that premature expression of a transgenic TCRalphabeta diverts some developing thymocytes to a developmental pathway which resembles that of gamma delta cells. We found that most peripheral T cells with the HY-TCR in male mice have bypassed the RORgammat-positive CD4(+)8(+) (double positive, DP) stage to accumulate either as CD4(-)8(-) (double negative, DN) or as CD8alpha(+) T cells in lymph nodes or gut epithelium. Likewise, DN TCRalphabeta cells in lymphoid tissue of female mice were not derived from DP thymocytes.
conclusionThe results further support the hypothesis that the premature expression of the TCRalphabeta can divert DN thymocytes into gamma delta lineage cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.