Evidence map›Paper›PMID 1823140›Full record

ReviewMolecular neurobiology1991

GTP-binding proteins and potassium channels involved in synaptic plasticity and learning.

T J Nelson, D L Alkon

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Characterization of a GTP-binding protein implicated in both memory storage and interorganelle vesicle transport.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

T J NelsonNeural Systems Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892.
D L Alkon
National Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elevated calcium levels or other phenomena resulting from the blockage of the potassium channels. A wide variety of cellular phenomena, from transcriptional changes to axonal transport, are thus capable of being initiated by these events.

Indexed as

Signal TransductionAnimalsCalciumConditioning, ClassicalGTP-Binding ProteinsIon Channel GatingLearningMemoryNeuronal PlasticityPhosphorylationPotassiumPotassium ChannelsProtein Processing, Post-TranslationalProtein-Tyrosine KinasesProto-Oncogene Proteins p21(ras)RabbitsCalciumGTP-Binding ProteinsPotassiumPotassium ChannelsProtein-Tyrosine KinasesProto-Oncogene Proteins p21(ras)

Identifiers

PMID1823140
OpenAlexW2051854029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.