ArticleProceedings of the National Academy of Sciences of the United States of America2008
The myocardin-related transcription factor, MASTR, cooperates with MyoD to activate skeletal muscle gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Genome-Wide Analysis of MAMSTR Transcription Factor-Binding Sites via ChIP-Seq in Porcine Skeletal Muscle Fibroblasts.Animals : an open access journal from MDPI · 2023Article
- The landscape of chromatin accessibility in skeletal muscle during embryonic development in pigs.Journal of animal science and biotechnology · 2021Article
- Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy.Scientific reports · 2018Article
- Article
- Myocardin-related transcription factors are required for skeletal muscle development.Development (Cambridge, England) · 2016Article
- Myocardin Family Members Drive Formation of Caveolae.PloS one · 2015Article
- Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes.The Journal of biological chemistry · 2012Article
- Investigation of four porcine candidate genes (H-FABP, MYOD1, UCP3 and MASTR) for meat quality traits in Large White pigs.Molecular biology reports · 2012Article
- MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration.Genes & development · 2012Article
- Mef2d acts upstream of muscle identity genes and couples lateral myogenesis to dermomyotome formation in Xenopus laevis.PloS one · 2012Article
- Skeletal muscle differentiation and fusion are regulated by the BAR-containing Rho-GTPase-activating protein (Rho-GAP), GRAF1.The Journal of biological chemistry · 2011Article
- Focal adhesion kinase is essential for cardiac looping and multichamber heart formation.Genesis (New York, N.Y. : 2000) · 2010Article
- Kruppel-like factor 2 cooperates with the ETS family protein ERG to activate Flk1 expression during vascular development.Development (Cambridge, England) · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The myocardin family proteins (myocardin, MRTF-A, and MRTF-B) are serum response factor (SRF) cofactors and potent transcription activators. Gene-ablation studies have indicated important developmental functions for myocardin family proteins primarily in regulation of cardiac and smooth muscle development. Using Xenopus genome and cDNA databases, we identified a myocardin-related transcription factor expressed specifically in the skeletal muscle lineage. Synteny and sequence alignments indicate that this gene is the frog orthologue of mouse MASTR [Creemers EE, Sutherland LB, Oh J, Barbosa AC, Olson EN (2006) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol Cell 23:83-96]. Inhibition of MASTR function in the Xenopus embryo by using dominant-negative constructions or morpholino knockdown results in a dramatic reduction in expression of skeletal muscle marker genes. Overexpression of MASTR in whole embryos or embryonic tissue explants induces ectopic expression of muscle marker genes. Furthermore, MASTR cooperates with the myogenic regulatory factors MyoD and Myf5 to activate transcription of skeletal muscle genes. An essential function for MASTR in regulation of myogenic development in the vertebrate embryo has not been previously indicated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.