ArticleBMJ (Clinical research ed.)2008
Impact of functional status at six months on long term survival in patients with ischaemic stroke: prospective cohort studies.
Article in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 6 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- Association of the systemic immune-inflammation index (SII) and clinical outcomes in patients with stroke: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- Longer term patient management following stroke: A systematic review.International journal of stroke : official journal of the International Stroke Society · 2021Pooled it
- Pooled it
- Risk analysis of new oral anticoagulants for gastrointestinal bleeding and intracranial hemorrhage in atrial fibrillation patients: a systematic review and network meta-analysis.Journal of Zhejiang University. Science. B · 2017Pooled it
- Consistency of safety and efficacy of new oral anticoagulants across subgroups of patients with atrial fibrillation.PloS one · 2014Pooled it
- Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis.Lancet (London, England) · 2012Pooled it
- Fluoxetine to improve functional outcomes in patients after acute stroke: the FOCUS RCT.Health technology assessment (Winchester, England) · 2020Trial
- Factors contributing to post-stroke health care utilization and costs, secondary results from the life after stroke (LAST) study.BMC health services research · 2020Trial
- Trial
- Trial
- Outcomes and costs of left atrial appendage closure from randomized controlled trial and real-world experience relative to oral anticoagulation.European heart journal · 2016Trial
- Cerebrolysin combined with rehabilitation promotes motor recovery in patients with severe motor impairment after stroke.BMC neurology · 2016Trial
- Trial
- Trial
- The synergistic effect of functional status and comorbidity burden on mortality: a 16-year survival analysis.PloS one · 2014Trial
- The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.Lancet (London, England) · 2012Trial
- Trial
- Comparative Efficacy of Exercise Modalities for Motor Function Recovery After Acute Ischemic Stroke: A Systematic Review and Bayesian Network Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice.European stroke journal · 2026Article
- A multimodal individualized long-term intervention to prevent functional decline after stroke (LAST-long): a single blinded randomised controlled trial.The Lancet regional health. Europe · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the impact on long term survival of functional status at six months after ischaemic stroke.
designProspective cohort study. Settings Three cohorts: Oxfordshire community stroke project, Lothian stroke register, and the first international stroke trial (in the United Kingdom).
participants7710 patients with ischaemic stroke registered between 1981 and 2000 and followed up for a maximum of 19 years.
main outcome measuresFunctional status at six months after stroke assessed with modified Rankin scale or "two simple questions." Mortality during follow-up. Survival analysis with Kaplan-Meier curves, log rank test, and Cox's regression model.
resultsIn a combined analysis of all three cohorts, among patients who survived to assessment six months after the index stroke, the subsequent median length of survival among those independent in daily living and those dependent was 9.7 years (95% confidence interval 8.9 to 10.6) and 6.0 years (5.7 to 6.4), respectively. In a combined analysis of the Oxfordshire and Lothian cohorts, subsequent median survival fell progressively from 12.9 years (10.0 to 15.9) for patients with a Rankin score of 0-1 at six months after the stroke to 2.5 years (1.4 to 3.5) for patients with a Rankin score of 5. All previously stated differences in median survival were significant (log rank test P<0.001). The influence of functional outcome on survival remained significant (P<0.05) in each cohort after adjustment for relevant covariates (such as age, presence of atrial fibrillation, visible infarct on computed tomography, subtype of stroke) in a Cox's regression model.
conclusionFunctional status six months after an ischaemic stroke is associated with long term survival. Early interventions that reduce dependency at six months might have positive effects on long term survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.