ArticleRespiratory research2008
Chlamydophila spp. infection in horses with recurrent airway obstruction: similarities to human chronic obstructive disease.
Article in Respiratory research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Decision Making in Severe Equine Asthma-Diagnosis and Monitoring.Animals : an open access journal from MDPI · 2023Review
- Equine Psittacosis and the Emergence ofAnimals : an open access journal from MDPI · 2023Article
- Detection ofJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Article
- Serological and Histopathological Investigation ofArchives of Razi Institute · 2022Article
- A 25-year retrospective study ofJournal of medical microbiology · 2021Article
- Tracheal microbial populations in horses with moderate asthma.Journal of veterinary internal medicine · 2020Article
- An epizootic of Chlamydia psittaci equine reproductive loss associated with suspected spillover from native Australian parrots.Emerging microbes & infections · 2018Article
- An outbreak of psittacosis at a veterinary school demonstrating a novel source of infection.One health (Amsterdam, Netherlands) · 2017Article
- Article
- Evolution to a chronic disease niche correlates with increased sensitivity to tryptophan availability for the obligate intracellular bacterium Chlamydia pneumoniae.Journal of bacteriology · 2014Review
- The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response.The Journal of infectious diseases · 2014Article
- Serosurveillance of infectious agents in equines of the Central Valley of Costa Rica.Open veterinary journal · 2014Article
- Evaluation of pulmonary dysfunctions and acid-base imbalances induced by Chlamydia psittaci in a bovine model of respiratory infection.Multidisciplinary respiratory medicine · 2014Article
- Article
- Article
- A bovine model of respiratory Chlamydia psittaci infection: challenge dose titration.PloS one · 2012Article
- Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells.Microbial pathogenesis · 2010Article
- Identifying catalytic residues in CPAF, a Chlamydia-secreted protease.Archives of biochemistry and biophysics · 2009Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrent airway obstruction (RAO) in horses is a naturally occurring dust-induced disease mainly characterized by bronchiolitis which shows histological and pathophysiological similarities to human chronic obstructive pulmonary disease (COPD). In human COPD previous investigations indicated an association with Chlamydophila psittaci infection. The present study was designed (1) to clarify a possible role of this infectious agent in RAO and (2) to investigate the suitability of this equine disorder as a model for human COPD.
methodsClinico-pathological parameters of a total of 45 horses (25 horses with clinical signs of RAO and 20 clinically healthy controls) were compared to histological findings in lung tissue samples and infection by Chlamydiaceae using light microscopy, immunohistochemistry, and PCR.
resultsHorses with clinical signs of RAO vs. controls revealed more inflammatory changes in histology (p = 0.01), and a higher detection rate of Chlamydia psittaci antigens in all cells (p < 0.001) and bronchiolar epithelial cells alone (p < 0.001) by immunohistochemistry. The abundance of chlamydial inclusions increased with the severity of disease. PCR was positive in 60% of horses with RAO vs. 45% of the controls (p = 0.316). OmpA sequencing identified Chlamydophila psittaci (n = 9) and Chlamydophila abortus (n = 13) in both groups with no significant differences. Within the group of clinically healthy horses subgroups with no changes (n = 15) and slight inflammation of the small airways (n = 5) were identified. Also in the group of animals with RAO subgroups with slight (n = 16) and severe (n = 9) bronchiolitis could be formed. These four subgroups can be separated in parts by the number of cells positive for Chlamydia psittaci antigens.
conclusionChlamydophila psittaci or abortus were present in the lung of both clinically healthy horses and those with RAO. Immunohistochemistry revealed acute chlamydial infections with inflammation in RAO horses, whereas in clinically healthy animals mostly persistent chlamydial infection and no inflammatory reactions were seen. Stable dust as the known fundamental abiotic factor in RAO is comparable to smoking in human disease. These results show that RAO can be used as a model for human COPD.
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