ArticleBMC microbiology2008
Ability of Lactobacillus fermentum to overcome host alpha-galactosidase deficiency, as evidenced by reduction of hydrogen excretion in rats consuming soya alpha-galacto-oligosaccharides.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Optimization of Mixed Inulin, Fructooligosaccharides, and Galactooligosaccharides as Prebiotics for Stimulation of Probiotics Growth and Function.Foods (Basel, Switzerland) · 2023Article
- Article
- A proof of concept infant-microbiota associated rat model for studying the role of gut microbiota and alleviation potential ofFrontiers in nutrition · 2022Article
- Potentiated In Vitro Probiotic Activities of Lactobacillus fermentum LfQi6 Biofilm Biomass Versus Planktonic Culture.Probiotics and antimicrobial proteins · 2020Article
- Effect ofFoods (Basel, Switzerland) · 2020Article
- Probiotic and technological properties of Lactobacillus spp. strains from the human stomach in the search for potential candidates against gastric microbial dysbiosis.Frontiers in microbiology · 2014Article
- Thermostability of Probiotics and Their α -Galactosidases and the Potential for Bean Products.Biotechnology research international · 2014Article
- Identification of Lactobacillus plantarum, Lactobacillus pentosus and Lactobacillus fermentum from honey stomach of honeybee.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
- Risk assessment of genetically modified lactic acid bacteria using the concept of substantial equivalence.Current microbiology · 2010Article
- Functionality of sortase A in Lactococcus lactis.Applied and environmental microbiology · 2010Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSoya and its derivatives represent nutritionally high quality food products whose major drawback is their high content of alpha-galacto-oligosaccharides. These are not digested in the small intestine due to the natural absence of tissular alpha-galactosidase in mammals. The passage of these carbohydrates to the large intestine makes them available for fermentation by gas-producing bacteria leading to intestinal flatulence. The aim of the work reported here was to assess the ability of alpha-galactosidase-producing lactobacilli to improve the digestibility of alpha-galacto-oligosaccharides in situ.
resultsGnotobiotic rats were orally fed with soy milk and placed in respiratory chambers designed to monitor fermentative gas excretion. The validity of the animal model was first checked using gnotobiotic rats monoassociated with a Clostridium butyricum hydrogen (H2)-producing strain. Ingestion of native soy milk by these rats caused significant H2 emission while ingestion of alpha-galacto-oligosaccharide-free soy milk did not, thus validating the experimental system. When native soy milk was fermented using the alpha-galactosidase-producing Lactobacillus fermentum CRL722 strain, the resulting product failed to induce H2 emission in rats thus validating the bacterial model. When L. fermentum CRL722 was coadministered with native soy milk, a significant reduction (50 %, P = 0.019) in H2 emission was observed, showing that alpha-galactosidase from L. fermentum CRL722 remained active in situ, in the gastrointestinal tract of rats monoassociated with C. butyricum. In human-microbiota associated rats, L. fermentum CRL722 also induced a significant reduction of H2 emission (70 %, P = 0.004).
conclusionThese results strongly suggest that L. fermentum alpha-galactosidase is able to partially alleviate alpha-galactosidase deficiency in rats. This offers interesting perspectives in various applications in which lactic acid bacteria could be used as a vector for delivery of digestive enzymes in man and animals.
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