ArticleInternational journal of chronic obstructive pulmonary disease2007
Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease.
Article in International journal of chronic obstructive pulmonary disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Increased Frequency of Angiotensin-Converting Enzyme D Allele in Asian Patients With Chronic Obstructive Pulmonary Disease: An Updated Meta-Analysis.The clinical respiratory journal · 2024Pooled it
- Pooled it
- Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis.BioMed research international · 2016Pooled it
- An updated meta-analysis on association between angiotensin I-converting enzyme gene insertion/deletion polymorphism and cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association of angiotensin-converting enzyme gene I/D polymorphism with chronic obstructive pulmonary disease: a meta-analysis.Journal of the renin-angiotensin-aldosterone system : JRAASPooled it
- Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease.Journal of medical biochemistry · 2023Article
- Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population.Molecular biology research communications · 2019Article
- Impact of I/D polymorphism of ACE gene on risk of development and course of chronic obstructive pulmonary disease.Archives of medical science : AMS · 2016Article
- Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression.Translational psychiatry · 2013Article
- Angiotensin-converting enzyme gene insertion/deletion polymorphism with metabolic syndrome in Turkish patients.Journal of endocrinological investigation · 2013Article
- Genetic influences on right ventricular systolic pressure (RVSP) in chronic obstructive pulmonary disease (COPD).BMC pulmonary medicine · 2012Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
- Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities.Therapeutic advances in chronic disease · 2010Article
- The aging immune system and its relationship to the development of chronic obstructive pulmonary disease.Proceedings of the American Thoracic Society · 2009Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While tobacco smoking is the main risk factor for chronic obstructive pulmonary disease (COPD) only a fraction of smokers go on to develop the disease. We investigated the relationship between the insertion (I)--deletion (D) polymorphisms in the Angiotensin converting enzyme (ACE) gene and the risk of developing COPD in smokers by determining the distribution of the ACE genotypes (DD, ID and II) in 151 life-long male smokers. 74 of the smokers had developed COPD (62 +/- 2 years; FEV1 44 +/- 6% reference) whereas the rest retained normal lung function (56 +/- 2 yrs; FEV1 95 +/- 3% reference). In addition, we genotyped 159 males recruited randomly from the general population. The prevalence of the DD genotype was highest (p = 0.01) in the smokers that developed COPD and its presence was associated with a 2-fold increase in the risk for COPD (OR 2.2; IC95% 1.1 to 5.5). Surprisingly, the 151 individuals in the smoking population did not demonstrate Hardy-Weinberg equilibrium unlike the 159 recruited from the general population. Our results suggest that ACE polymorphisms are associated with both the smoking history of an individual and their risk of developing COPD.
Indexed as
Identifiers
18229571PMC2695206W123632041What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.