ArticleCell stress & chaperones2007
Differential recruitment of PKC isoforms in HeLa cells during redox stress.
Article in Cell stress & chaperones, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- miR-200c inhibition and catalase accelerate diabetic wound healing.Journal of biomedical science · 2025Article
- Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling.Frontiers in cell and developmental biology · 2024Article
- p66Shc in Cardiovascular Pathology.Cells · 2022Review
- Oxidative Stress Underlies the Ischemia/Reperfusion-Induced Internalization and Degradation of AMPA Receptors.International journal of molecular sciences · 2021Article
- Update on Calcium Signaling in Cystic Fibrosis Lung Disease.Frontiers in pharmacology · 2021Review
- Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies.Nutrition & metabolism · 2018Review
- Article
- Protein Kinase C β: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight Gain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions.International journal of molecular sciences · 2015Article
- Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance.Journal of clinical biochemistry and nutrition · 2015Review
- Emerging role of protein kinase C in energy homeostasis: A brief overview.World journal of diabetes · 2014Review
- Intra-lesional injection of the novel PKC activator EBC-46 rapidly ablates tumors in mouse models.PloS one · 2014Article
- CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.PloS one · 2014Article
- Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction.BioMed research international · 2014Review
- Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ.Frontiers in oncology · 2013Review
- Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C.Oxidative medicine and cellular longevity · 2013Review
- The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells.Cell cycle (Georgetown, Tex.) · 2012Article
- Protein kinases and phosphatases in the control of cell fate.Enzyme research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The protein kinase C (PKC) family is a major transducer of several intracellular pathways. In confirmation of this important role, PKCs exhibit high molecular heterogeneity, because they occur in at least 10 different isoforms differing in biochemical properties and sensitivity to activators. In this report we focused on the ability of different redox agents to induce modification of intracellular distribution of specific PKC isoforms in HeLa cells. To this end we utilized a panel of green fluorescent protein (GFP) chimeras and a high-speed digital imaging system. We observed a remarkable complexity of PKC signalling patterns occurring during redox stress with marked differences among PKC isoforms also belonging to the same subgroup. Moreover our results suggest that modifications of the intracellular redox state can modulate the responsiveness of specific PKC isoforms and, in turn, change the sensitivity of the different isoforms to cell stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.