ArticleCurrent microbiology2008
InlA and InlC2 of Listeria monocytogenes serotype 4b are two internalin proteins eliciting humoral immune responses common to listerial infection of various host species.
Article in Current microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Validation of Predicted Virulence Factors inToxins · 2019Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- New development in studies of formyl-peptide receptors: critical roles in host defense.Journal of leukocyte biology · 2016Review
- Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes.Scientific reports · 2012Article
- Recombination and positive selection contributed to the evolution of Listeria monocytogenes lineages III and IV, two distinct and well supported uncommon L. monocytogenes lineages.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Comparative genomic analysis reveals significant enrichment of mobile genetic elements and genes encoding surface structure-proteins in hospital-associated clonal complex 2 Enterococcus faecalis.BMC microbiology · 2011Article
- The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosis.Infection and immunity · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The internalins InlA and InlC2 are encoded proteins from two strongly immunoreactive clones recently identified by differential immunoscreening of a Listeria monocytogenes serotype 4b genomic expression library during the search of the gene products of L. monocytogenes specifically induced in vivo during infection (Yu WL, Dan H, Lin M. J Med Microbiol 56:888-895, 2007). In this study, we examined the humoral immune response against InlA and InlC2 in various L. monocytogenes-infected hosts using Western blots. InlA and InlC2 were recognized by antibodies in experimentally infected rabbits but not by antisera from rabbits immunized with the heat-killed bacterium. Similar strong immunological reactions to InlA and InlC2 were seen with antisera from infected guinea pigs, cattle, and sheep but not with those from the animals (guinea pigs or sheep) receiving heat-killed bacteria. This study provides the first experimental evidence that InlA and InlC2 are the in vivo induced or upregulated antigens for humoral immune responses that are common to listerial infection of various host species. These two immunogenic proteins may thus be explored as reagents for the laboratory diagnosis of listeriosis or candidates for vaccine development.
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