ArticleMedical & biological engineering & computing2008
The development of the heart and microcirculation: role of shear stress.
Article in Medical & biological engineering & computing, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- In Vitro Models to Study Fibroelastic Remodeling of the Endocardium in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Forcing the code: tension modulates signaling to drive morphogenesis and malignancy.Genes & development · 2025Review
- An open-source, battery-powered, low-cost, and dual-channel pneumatic pulse generator for microfluidic cell-stretch assays.HardwareX · 2024Article
- Deciphering the emerging landscape of HOX genes in cardiovascular biology, atherosclerosis and beyond (Review).International journal of molecular medicine · 2024Article
- Segmentation of beating embryonic heart structures from 4-D OCT images using deep learning.Biomedical optics express · 2023Article
- Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart.Journal of cardiovascular development and disease · 2022Review
- Haemodynamic dependence of mechano-genetic evolution of the cardiovascular system in Japanese medaka.Journal of the Royal Society, Interface · 2021Article
- Elongational Stresses and Cells.Cells · 2021Review
- Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease.Journal of cardiovascular development and disease · 2021Review
- Optogenetic cardiac pacing in cultured mouse embryos under imaging guidance.Journal of biophotonics · 2020Article
- Semi-automated shear stress measurements in developing embryonic hearts.Biomedical optics express · 2020Article
- A Flow Induced Autoimmune Response and Accelerated Senescence of Red Blood Cells in Cardiovascular Devices.Scientific reports · 2019Article
- Primary cilia defects causing mitral valve prolapse.Science translational medicine · 2019Article
- Analysis of HOXB1 gene in a cohort of patients with sporadic ventricular septal defect.Molecular biology reports · 2018Article
- Placental Origins of Chronic Disease.Physiological reviews · 2016Review
- Hox Genes in Cardiovascular Development and Diseases.Journal of developmental biology · 2016Review
- Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics.Journal of cardiovascular development and disease · 2016Article
- Genetic and flow anomalies in congenital heart disease.AIMS genetics · 2016Article
- Fluorescence-based force/tension sensors: a novel tool to visualize mechanical forces in structural proteins in live cells.Antioxidants & redox signaling · 2014Review
- Orientation-independent rapid pulsatile flow measurement using dual-angle Doppler OCT.Biomedical optics express · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is evident that hemodynamic factors have a dominant function already during early cardiogenesis. Flow and ensuing shear stress are sensed by endothelial cells by, ciliary modified, cytoskeletal deformation which then activates a number of subcellular structures and molecules. Shear stress dependent changes mostly converge towards NF kappa B signaling and DNA binding, thereby altering metabolic paths and influencing differentiation of the cells. Geometry of the vascular system heavily affects the flow and shear patterns, as is the case in the adult vasculature where atheroprone areas nicely coincide with the frequency of the primary cilium as shear stress sensor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.