ReviewNeurology2008
Practical approaches to incidental findings in brain imaging research.
Review in Neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2009Pooled it
- Trial
- Incidental findings on brain magnetic resonance imaging of children with sickle cell disease.Pediatrics · 2010Trial
- Ethical Governance Strategies for the Responsible Innovation of Neurotechnologies: A Scoping Review.Journal of bioethical inquiry · 2025Article
- The Realization of Portable MRI for Indigenous Communities in the USA and Canada.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2024Article
- An Equity and Justice-Informed Ethical Framework to Guide Incidental Findings in Brain Imaging Research.Clinics and practice · 2023Article
- Incidental Findings Among Youth Participating in Multimodal Imaging Research: Characteristics of Findings and Description of a Management Approach.Frontiers in pediatrics · 2022Article
- Taking it to the bank: the ethical management of individual findings arising in secondary research.Journal of medical ethics · 2021Article
- Nonmalignant meningioma and vestibular schwannoma incidence trends in the United States, 2004-2017.Cancer · 2021Article
- A Just Standard: The Ethical Management of Incidental Findings in Brain Imaging Research.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2021Article
- The Impact of Incidental Findings Detected During Brain Imaging on Research Participants of the Rotterdam Study: An Interview Study.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2020Article
- A Social Constructivism Decision-Making Approach to Managing Incidental Findings in Neuroimaging Research.Ethics & behavior · 2018Article
- Discovery and informing research participants of incidental findings detected in brain magnetic resonance imaging studies: Review and multi-institutional study.Brain and behavior · 2017Review
- Ethical framework for the detection, management and communication of incidental findings in imaging studies, building on an interview study of researchers' practices and perspectives.BMC medical ethics · 2017Article
- Torcular pseudomass: a potential diagnostic pitfall in infants and young children.Pediatric radiology · 2017Article
- MR imaging of the brain in large cohort studies: feasibility report of the population- and patient-based BiDirect study.European radiology · 2017Article
- Disclosing neuroimaging incidental findings: a qualitative thematic analysis of health literacy challenges.BMC medical ethics · 2016Article
- Evolution of universal review and disclosure of MRI reports to research participants.Brain and behavior · 2016Review
- A Systematic Review of the Management of Incidental Findings in Genomic Research.BEOnline : journal of the West African bioethics training program · 2016Article
- Incidental findings in population imaging revisited.European journal of epidemiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
A decade of empirical work in brain imaging, genomics, and other areas of research has yielded new knowledge about the frequency of incidental findings, investigator responsibility, and risks and benefits of disclosure. Straightforward guidance for handling such findings of possible clinical significance, however, has been elusive. In early work focusing on imaging studies of the brain, we suggested that investigators and institutional review boards must anticipate and articulate plans for handling incidental findings. Here we provide a detailed analysis of different approaches to the problem and evaluate their merits in the context of the goals and setting of the research and the involvement of neurologists, radiologists, and other physicians. Protecting subject welfare and privacy, as well as ensuring scientific integrity, are the highest priorities in making choices about how to handle incidental findings. Forethought and clarity will enable these goals without overburdening research conducted within or outside the medical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.