ArticleThe Journal of general physiology2008
The muscle chloride channel ClC-1 is not directly regulated by intracellular ATP.
Article in The Journal of general physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Molecular basis of ClC-6 function and its impairment in human disease.Science advances · 2023Article
- Depletion of ATP Limits Membrane Excitability of Skeletal Muscle by Increasing Both ClC1-Open Probability and Membrane Conductance.Frontiers in neurology · 2020Article
- Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle.The Journal of general physiology · 2016Review
- ClC-1 chloride channels: state-of-the-art research and future challenges.Frontiers in cellular neuroscience · 2015Review
- Binding of ATP to the CBS domains in the C-terminal region of CLC-1.The Journal of general physiology · 2011Article
- Chloride currents from the transverse tubular system in adult mammalian skeletal muscle fibers.The Journal of general physiology · 2011Article
- Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle.The Journal of general physiology · 2010Article
- ClC transporters: discoveries and challenges in defining the mechanisms underlying function and regulation of ClC-5.Pflugers Archiv : European journal of physiology · 2010Review
- Chloride channels: often enigmatic, rarely predictable.Annual review of physiology · 2010Review
- Extracellular ATP inhibits chloride channels in mature mammalian skeletal muscle by activating P2Y1 receptors.The Journal of physiology · 2009Article
- Regulation of ClC-1 and KATP channels in action potential-firing fast-twitch muscle fibers.The Journal of general physiology · 2009Article
- Intracellular regulation of human ClC-5 by adenine nucleotides.EMBO reports · 2009Article
- ATP binding to the C terminus of the Arabidopsis thaliana nitrate/proton antiporter, AtCLCa, regulates nitrate transport into plant vacuoles.The Journal of biological chemistry · 2009Article
- Physiological roles of CLC Cl(-)/H (+) exchangers in renal proximal tubules.Pflugers Archiv : European journal of physiology · 2009Review
- Review. CLC-mediated anion transport in plant cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- ATP inhibition of CLC-1 is controlled by oxidation and reduction.The Journal of general physiology · 2008Article
- To ATP or not to ATP: this is the question.The Journal of general physiology · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
ClC-1 belongs to the gene family of CLC Cl(-) channels and Cl(-)/H(+) antiporters. It is the major skeletal muscle chloride channel and is mutated in dominant and recessive myotonia. In addition to the membrane-embedded part, all mammalian CLC proteins possess a large cytoplasmic C-terminal domain that bears two so-called CBS (from cystathionine-beta-synthase) domains. Several studies indicate that these domains might be involved in nucleotide binding and regulation. In particular, Bennetts et al. (J. Biol. Chem. 2005. 280:32452-32458) reported that the voltage dependence of hClC-1 expressed in HEK cells is regulated by intracellular ATP and other nucleotides. Moreover, very recently, Bennetts et al. (J. Biol. Chem. 2007. 282:32780-32791) and Tseng et al. (J. Gen. Physiol. 2007. 130:217-221) reported that the ATP effect was enhanced by intracellular acidification. Here, we show that in striking contrast with these findings, human ClC-1, expressed in Xenopus oocytes and studied with the inside-out configuration of the patch-clamp technique, is completely insensitive to intracellular ATP at concentrations up to 10 mM, at neutral pH (pH 7.3) as well as at slightly acidic pH (pH 6.2). These results have implications for a general understanding of nucleotide regulation of CLC proteins and for the physiological role of ClC-1 in muscle excitation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.