ArticleMicrobiology (Reading, England)2008
Functional analyses of heterotrimeric G protein G alpha and G beta subunits in Gibberella zeae.
Article in Microbiology (Reading, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 119 citations in OpenAlex.
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- Metabolic reprogramming landscape orchestrating chlamydospore formation inFrontiers in microbiology · 2026Article
- Integrative perspectives on glycosylation networks in fungi and oomycetes.Journal of microbiology (Seoul, Korea) · 2025Review
- Best practices in plant fluorescence imaging and reporting: A primer.The Plant cell · 2025Review
- Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis.PLoS pathogens · 2025Article
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- A winged-helix DNA-binding protein is essential for self-fertility during sexual development of the homothallic fungusmSphere · 2024Article
- Advances in UnderstandingGenes · 2024Review
- A non-pheromone GPCR is essential for meiosis and ascosporogenesis in the wheat scab fungus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Herbicide 2,4-dichlorophenoxyacetic acid interferes with MAP kinase signaling in Fusarium graminearum and is inhibitory to fungal growth and pathogenesis.Stress biology · 2023Article
- Review
- Effect of Compactin on the Mycotoxin Production and Expression of Related Biosynthetic and Regulatory Genes in ToxigenicMicroorganisms · 2022Article
- Quantitative multiplexed proteomics analysis reveals reshaping of the lysine 2-hydroxyisobutyrylome in Fusarium graminearum by tebuconazole.BMC genomics · 2022Article
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- Transcriptome Dynamics Underlying Chlamydospore Formation inFrontiers in microbiology · 2021Article
- Gα3 subunit Thga3 positively regulates conidiation, mycoparasitism, chitinase activity, and hydrophobicity of Trichoderma harzianum.AMB Express · 2020Article
- Coregulation of dimorphism and symbiosis by cyclic AMP signaling in the lichenized fungusProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome sequence and spore germination-associated transcriptome analysis of Corynespora cassiicola from cucumber.BMC microbiology · 2020Article
- An expanded subfamily of G-protein-coupled receptor genes in Fusarium graminearum required for wheat infection.Nature microbiology · 2019Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homothallic ascomycete fungus Gibberella zeae (anamorph: Fusarium graminearum) is a major toxigenic plant pathogen that causes head blight disease on small-grain cereals. The fungus produces the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) in infected hosts, posing a threat to human and animal health. Despite its agricultural and toxicological importance, the molecular mechanisms underlying its growth, development and virulence remain largely unknown. To better understand such mechanisms, we studied the heterotrimeric G proteins of G. zeae, which are known to control crucial signalling pathways that regulate various cellular and developmental responses in fungi. Three putative Galpha subunits, GzGPA1, GzGPA2 and GzGPA3, and one Gbeta subunit, GzGPB1, were identified in the F. graminearum genome. Deletion of GzGPA1, a homologue of the Aspergillus nidulans Galpha gene fadA, resulted in female sterility and enhanced DON and ZEA production, suggesting that GzGPA1 is required for normal sexual reproduction and repression of toxin biosynthesis. The production of DON and ZEA was also enhanced in the GzGPB1 mutant, suggesting that both Galpha GzGPA1 and Gbeta GzGPB1 negatively control mycotoxin production. Deletion of GzGPA2, which encodes a Galpha protein similar to A. nidulans GanB, caused reduced pathogenicity and increased chitin accumulation in the cell wall, implying that GzGPA2 has multiple functions. Our study shows that G. zeae heterotrimeric G protein subunits can regulate vegetative growth, sexual development, toxin production and pathogenicity.
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