ArticleAntimicrobial agents and chemotherapy2008
Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (group B streptococcus), Haemophilus ducreyi, and vaginal Lactobacillus by 3-O-octyl-sn-glycerol.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Antimicrobial Photodynamic Inactivation: An Alternative for Group BAntioxidants (Basel, Switzerland) · 2023Article
- Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.Frontiers in pediatrics · 2018Review
- Formulation and characterization of polymeric films containing combinations of antiretrovirals (ARVs) for HIV prevention.Pharmaceutical research · 2015Article
- Development of a liposome microbicide formulation for vaginal delivery of octylglycerol for HIV prevention.Drug development and industrial pharmacy · 2012Article
- Testing of viscous anti-HIV microbicides using Lactobacillus.Journal of microbiological methods · 2012Article
- Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity.PloS one · 2012Article
- Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission.Drug delivery and translational research · 2011Article
- In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide.PloS one · 2010Article
- Evaluation of WLBU2 peptide and 3-O-octyl-sn-glycerol lipid as active ingredients for a topical microbicide formulation targeting Chlamydia trachomatis.Antimicrobial agents and chemotherapy · 2010Article
- Chlamydia trachomatis laboratory strains versus recent clinical isolates: implications for routine microbicide testing.Antimicrobial agents and chemotherapy · 2009Article
- Vaginal drug delivery systems for HIV prevention.The AAPS journal · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The microbicide candidate octylglycerol inactivates sexually transmitted bacterial pathogens at concentrations which spare normal vaginal flora (lactobacillus). Standard minimum microbicidal concentration assays and time-kill assays revealed the drug concentrations and times required for inactivation. Octylglycerol concentrations must exceed the binding capacity of any human serum albumin to be effective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.