ArticleMolecular and cellular biology2008
Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Nucleosome Assembly Protein 1 in Dinoflagellate Cells Without Architectural Nucleosomes.International journal of molecular sciences · 2026Article
- Somatic NAP1L1 p.D349E promotes cardiac hypertrophy through cGAS-STING-IFN signaling.Nature communications · 2025Article
- Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.The Journal of cell biology · 2025Article
- The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation.Scientific reports · 2018Article
- Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes.Molecular and cellular biology · 2016Article
- Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus.Molecular and cellular biology · 2016Article
- The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution.Nucleic acids research · 2014Article
- A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.Nucleic acids research · 2013Article
- Histone chaperones Nap1 and Vps75 regulate histone acetylation during transcription elongation.Molecular and cellular biology · 2013Article
- Overcoming the nucleosome barrier during transcript elongation.Trends in genetics : TIG · 2012Review
- Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Interaction with the histone chaperone Vps75 promotes nuclear localization and HAT activity of Rtt109 in vivo.Traffic (Copenhagen, Denmark) · 2011Article
- Transcriptional elongation and mRNA export are coregulated processes.Genetics research international · 2011Article
- In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo.Molecular and cellular biology · 2010Article
- Histone chaperones, histone acetylation, and the fluidity of the chromogenome.Journal of cellular physiology · 2010Article
- Nap1 and Chz1 have separate Htz1 nuclear import and assembly functions.Traffic (Copenhagen, Denmark) · 2010Article
- The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.Genes & development · 2008Article
- Histone chaperones in nucleosome eviction and histone exchange.Current opinion in structural biology · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chromatin remodeling is central to the regulation of transcription elongation. We demonstrate that the conserved Saccharomyces cerevisiae histone chaperone Nap1 associates with chromatin. We show that Nap1 regulates transcription of PHO5, and the increase in transcript level and the higher phosphatase activity plateau observed for Deltanap1 cells suggest that the net function of Nap1 is to facilitate nucleosome reassembly during transcription elongation. To further our understanding of histone chaperones in transcription elongation, we identified factors that regulate the function of Nap1 in this process. One factor investigated is an essential mRNA export and TREX complex component, Yra1. Nap1 interacts directly with Yra1 and genetically with other TREX complex components and the mRNA export factor Mex67. Additionally, we show that the recruitment of Nap1 to the coding region of actively transcribed genes is Yra1 dependent and that its recruitment to promoters is TREX complex independent. These observations suggest that Nap1 functions provide a new connection between transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.