ArticleBiophysical journal2008
Depolymerization-driven flow in nematode spermatozoa relates crawling speed to size and shape.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Persistent and polarized global actin flow is essential for directionality during cell migration.Nature cell biology · 2019Article
- On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility.Molecular biology of the cell · 2018Article
- On a poroviscoelastic model for cell crawling.Journal of mathematical biology · 2015Article
- Actin-myosin spatial patterns from a simplified isotropic viscoelastic model.Biophysical journal · 2014Article
- A conservative algorithm for parabolic problems in domains with moving boundaries.Journal of computational physics · 2014Article
- A comparison of computational models for eukaryotic cell shape and motility.PLoS computational biology · 2012Review
- Reconstitution of amoeboid motility in vitro identifies a motor-independent mechanism for cell body retraction.Current biology : CB · 2011Article
- Cytopede: a three-dimensional tool for modeling cell motility on a flat surface.Journal of computational biology : a journal of computational molecular cell biology · 2010Article
- The Moving Boundary Node Method: A level set-based, finite volume algorithm with applications to cell motility.Journal of computational physics · 2010Article
- Cytoskeletal cross-linking and bundling in motor-independent contraction.Current biology : CB · 2010Review
- Multiphase flow models of biogels from crawling cells to bacterial biofilms.HFSP journal · 2010Article
- Actin-myosin viscoelastic flow in the keratocyte lamellipod.Biophysical journal · 2009Article
- Biochemical mechanisms for regulating protrusion by nematode major sperm protein.Biophysical journal · 2009Article
- Sperm morphology and sperm velocity in passerine birds.Proceedings. Biological sciences · 2009Article
- Continuum modeling of forces in growing viscoelastic cytoskeletal networks.Journal of theoretical biology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cell crawling is an inherently physical process that includes protrusion of the leading edge, adhesion to the substrate, and advance of the trailing cell body. Research into advance of the cell body has focused on actomyosin contraction, with cytoskeletal disassembly regarded as incidental, rather than causative; however, extracts from nematode spermatozoa, which use Major Sperm Protein rather than actin, provide at least one example where cytoskeletal disassembly apparently generates force in the absence of molecular motors. To test whether depolymerization can explain force production during nematode sperm crawling, we constructed a mathematical model that simultaneously describes the dynamics of both the cytoskeleton and the cytosol. We also performed corresponding experiments using motile Caenorhabditis elegans spermatozoa. Our experiments reveal that crawling speed is an increasing function of both cell size and anterior-posterior elongation. The quantitative, depolymerization-driven model robustly predicts that cell speed should increase with cell size and yields a cytoskeletal disassembly rate that is consistent with previous measurements. Notably, the model requires anisotropic elasticity, with the cell being stiffer along the direction of motion, to accurately reproduce the dependence of speed on elongation. Our simulations also predict that speed should increase with cytoskeletal anisotropy and disassembly rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.