ReviewBasic & clinical pharmacology & toxicology2008
Late insights into early origins of disease.
Review in Basic & clinical pharmacology & toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Effects of tributyltin on placental and reproductive abnormalities in offspring.Archives of endocrinology and metabolism · 2024Review
- Placental outcomes of phthalate exposure.Reproductive toxicology (Elmsford, N.Y.) · 2021Review
- Persistent organic pollutants at the synapse: Shared phenotypes and converging mechanisms of developmental neurotoxicity.Developmental neurobiology · 2021Review
- What is useful research? The good, the bad, and the stable.Environmental health : a global access science source · 2020Article
- Article
- EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.Endocrine reviews · 2015Review
- Trace elements as paradigms of developmental neurotoxicants: Lead, methylmercury and arsenic.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015Review
- Growth in Inuit children exposed to polychlorinated biphenyls and lead during fetal development and childhood.Environmental research · 2014Article
- Neonatal tumours.Pediatric surgery international · 2013Review
- Indigenous peoples of North America: environmental exposures and reproductive justice.Environmental health perspectives · 2012Article
- A new framework for childhood health promotion: the role of policies and programs in building capacity and foundations of early childhood health.American journal of public health · 2012Review
- Developmental neurotoxicity: some old and new issues.ISRN toxicology · 2012Article
- Environmental exposures and development.Current opinion in pediatrics · 2010Review
- What does the pediatrician need to know about Alzheimer disease?Journal of developmental and behavioral pediatrics : JDBP · 2009Article
- Mercury and Selenium - A Review on Aspects Related to the Health of Human Populations in the Amazon.Environmental bioindicators · 2009Article
- Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging.Women's health (London, England) · 2009Article
- Facing the challenge of data transfer from animal models to humans: the case of persistent organohalogens.Environmental health : a global access science source · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Burgeoning research into early functional programming has opened a new perspective of developmental origins of disease and organ dysfunction. In examining the roots of this emerging paradigm, it appears that crucial observations were made already 25 years ago. Clear examples include the discoveries of foetal alcohol syndrome, cancer in daughters whose mothers had used diethylstilboestrol during pregnancy, and neurotoxicity of lead and methylmercury. However, this research was often considered controversial, scientific conclusions were cautiously hedged, and stakeholders demanded replication in excess. Recognition of the new paradigm was therefore delayed, preventive interventions even further so. In hindsight, and in light of the precautionary principle, the adverse effects incurred on public health and the environment would call for responsible judgment to balance reasonable scientific scepticism against the risks associated with inaction. The traditional scientific scrutiny whether confidence limits include the possibility of no effect must be modified to allow consideration of the likelihood of worst-case scenarios. Additional emphasis should be placed on the question: what could be known, given our study opportunities and methodologies? Our late insights into the early disease origins may then benefit science and prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.