ArticlePLoS computational biology2008
A quantitative study of the division cycle of Caulobacter crescentus stalked cells.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Influence of the Heme Nitric Oxide/Oxygen Binding Protein (H-NOX) on Cell Cycle Regulation in Caulobacter crescentus.Molecular & cellular proteomics : MCP · 2023Article
- Turing-pattern model of scaffolding proteins that establish spatial asymmetry during the cell cycle ofiScience · 2023Article
- Article
- A Self-Controlled and Self-Healing Model of Bacterial Cells.Membranes · 2022Article
- Evolution of Complex Regulation for Cell-Cycle Control.Genome biology and evolution · 2022Article
- Modeling the temporal dynamics of master regulators and CtrA proteolysis in Caulobacter crescentus cell cycle.PLoS computational biology · 2022Article
- The interplay of spatial organization and biochemistry in building blocks of cellular signalling pathways.Journal of the Royal Society, Interface · 2020Article
- Stochastic modeling and simulation of reaction-diffusion system with Hill function dynamics.BMC systems biology · 2017Article
- To grow is not enough: impact of noise on cell environmental response and fitness.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Dynamical Localization of DivL and PleC in the Asymmetric Division Cycle of Caulobacter crescentus: A Theoretical Investigation of Alternative Models.PLoS computational biology · 2015Article
- Dynamical modeling of the cell cycle and cell fate emergence in Caulobacter crescentus.PloS one · 2014Article
- Refining ensembles of predicted gene regulatory networks based on characteristic interaction sets.PloS one · 2014Article
- Computational and genetic reduction of a cell cycle to its simplest, primordial components.PLoS biology · 2013Article
- A quantitative study of gene regulatory pathways in Bacillus subtilis for virulence and competence phenotype by quorum sensing.Systems and synthetic biology · 2013Article
- Potential role of a bistable histidine kinase switch in the asymmetric division cycle of Caulobacter crescentus.PLoS computational biology · 2013Article
- Article
- A boolean model of the cardiac gene regulatory network determining first and second heart field identity.PloS one · 2012Article
- Network Medicine: New Paradigm in the -Omics Era.Anatomy & physiology : current research · 2011Article
- Temporal and spatial oscillations in bacteria.Nature reviews. Microbiology · 2011Review
- Single-gene tuning of Caulobacter cell cycle period and noise, swarming motility, and surface adhesion.Molecular systems biology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome replication and partitioning to daughter cells. From published experimental evidence, we propose a molecular mechanism for control of the cell division cycle in Caulobacter crescentus. The mechanism, which is based on the synthesis and degradation of three "master regulator" proteins (CtrA, GcrA, and DnaA), is converted into a quantitative model, in order to study the temporal dynamics of these and other cell cycle proteins. The model accounts for important details of the physiology, biochemistry, and genetics of cell cycle control in stalked C. crescentus cell. It reproduces protein time courses in wild-type cells, mimics correctly the phenotypes of many mutant strains, and predicts the phenotypes of currently uncharacterized mutants. Since many of the proteins involved in regulating the cell cycle of C. crescentus are conserved among many genera of alpha-proteobacteria, the proposed mechanism may be applicable to other species of importance in agriculture and medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.