ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- An atypical ubiquitin ligase at the heart of neural development and programmed axon degeneration.Neural regeneration research · 2022Review
- A mutation linked tomicroPublication biology · 2022Article
- Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub.eLife · 2019Article
- Article
- Defining Minimal Binding Regions in Regulator of Presynaptic Morphology 1 (RPM-1) UsingThe Journal of biological chemistry · 2017Article
- The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration.Neural development · 2016Review
- Developmental Function of the PHR Protein RPM-1 Is Required for Learning in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2015Article
- The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons.Cell reports · 2015Article
- The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin.PLoS genetics · 2014Article
- RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons.Neural development · 2014Article
- RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.PLoS genetics · 2014Article
- The role of ubiquitin-mediated pathways in regulating synaptic development, axonal degeneration and regeneration: insights from fly and worm.The Journal of physiology · 2013Review
- Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.The EMBO journal · 2013Article
- Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.Neuron · 2012Article
- RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein.PLoS biology · 2012Article
- PPM-1, a PP2Cα/β phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans.Genetics · 2011Article
- Axon regeneration mechanisms: insights from C. elegans.Trends in cell biology · 2011Review
- Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons.Nature neuroscience · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Caenorhabditis elegans RPM-1 is a member of a conserved protein family, the PHR proteins, that includes human Pam, mouse Phr1, zebrafish Esrom, and Drosophila Highwire. PHR proteins play important roles in the development of the nervous system. In particular, mutations in rpm-1 cause a disruption of synaptic architecture, affecting the distribution of synaptic vesicles and the number of presynaptic densities. Using antibodies against RPM-1, we determined the localization of the endogenous RPM-1 protein in wild-type and in several mutants that affect synaptic development. Our analyses show that, in mature neurons, RPM-1 resides in a distinct region that is close to, but does not overlap with, the synaptic exo- and endocytosis domains. The localization of RPM-1 occurs independently of several proteins that function in the transport or assembly of synapse components, and its abundance is partially dependent on its binding partner the F-box protein FSN-1. RPM-1 has been shown to target the MAPKKK DLK-1 for degradation. We show that activated DLK-1 may be preferentially targeted for degradation. Furthermore, using transgene analysis, we identified a critical role of the conserved PHR domain of RPM-1 in its subcellular localization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.