ArticleInternational journal of hematology2008
Histiocytic sarcoma of the spleen: case report of asymptomatic onset of thrombocytopenia and complex imaging features.
Article in International journal of hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Primary splenic histiocytic sarcoma: A case report and review of literature.World journal of clinical cases · 2026Article
- Splenic histiocytic sarcoma: Disease progression from the perspective of pathophysiology.World journal of clinical cases · 2025Article
- Histiocytic Sarcoma: A Review and Update.International journal of molecular sciences · 2025Review
- Multimodality Imaging Features of Various Splenic Lesions: Clinical and Histopathologic Correlation.Journal of the Korean Society of Radiology · 2024Review
- Undifferentiated pleomorphic sarcoma of the spleen: a case report and literature review.Surgical case reports · 2023Article
- Primary splenic histiocytic sarcoma successfully treated with splenectomy: a case report and literature review.International cancer conference journal · 2022Article
- Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma.International journal of environmental research and public health · 2021Article
- Histiocytic sarcoma arising from a lymph node: a diagnostic conundrum.International cancer conference journal · 2021Article
- Thrombocytopenia with multiple splenic lesions - histiocytic sarcoma of the spleen without splenomegaly: A case report.World journal of clinical oncology · 2020Article
- Sudden unexpected death from an undiagnosed histiocytic sarcoma in an adolescent female.Forensic science, medicine, and pathology · 2016Article
- Laparoscopic splenectomy for histiocytic sarcoma of the spleen.World journal of gastrointestinal surgery · 2013Article
- Primary splenic histiocytic sarcoma complicated with prolonged idiopathic thrombocytopenia and secondary bone marrow involvement: a unique surgical case presenting with splenomegaly but non-nodular lesions.Diagnostic pathology · 2012Article
- Histiocytic sarcoma.Revista brasileira de hematologia e hemoterapia · 2011Article
- Histiocytic sarcoma with two immunohistopathologically distinct populations.International journal of hematology · 2010Article
- Hepatic Involvement of Histiocytic Sarcoma: CT and MRI Findings.Korean journal of radiologyArticle
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histiocytic sarcoma of the spleen, in which the malignant cells display morphologic and immunophenotypic features similar to those of mature tissue histiocytes, is a rare but potentially lethal condition that can remain asymptomatic or only mildly symptomatic for a long period of time. We studied a case of histiocytic sarcoma of the spleen in an 82-year-old woman with prolonged chronic thrombocytopenia that was non-responsive to steroid therapy. Ultrasonography, computed tomography, and magnetic resonance imaging showed a characteristically enlarged spleen and liver. Palliative irradiation therapy was clinically effective; however, disease progression proved lethal. Autopsy revealed the proliferation of tumor cells within the splenic sinus and the liver sinusoids, which displayed extreme hemophagocytosis and strong expression of the histiocytic markers CD68 (KP1 and PG-M1) and CD163. The postmortem diagnosis showed histiocytic sarcoma of the spleen with liver infiltration. This and previous reports indicate that early detection (facilitated by imaging and clinical features) and management may improve patient prognosis and survival. Histiocytic sarcoma of the spleen should be considered as a differential diagnosis in therapeutically unresponsive patients with chronic thrombocytopenia.
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