ArticleInternational journal of hematology2008
Role of Polycomb-group genes in sustaining activities of normal and malignant stem cells.
Article in International journal of hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating Geminin.PloS one · 2016Article
- Transcription of the Geminin gene is regulated by a negative-feedback loop.Molecular biology of the cell · 2014Article
- A network of epigenetic regulators guides developmental haematopoiesis in vivo.Nature cell biology · 2013Article
- Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.Molecular and cellular biology · 2013Article
- Hoxa9 transduction induces hematopoietic stem and progenitor cell activity through direct down-regulation of geminin protein.PloS one · 2013Article
- Article
- The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis.Critical reviews in oncogenesis · 2011Review
- Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First PcG complex 2 silences chromatin and encodes a histone code by methylating histone H3 at lysine 27. PcG complex 1 is, then, recruited by recognizing the histone code, and ubiquitinates histone H2A and/or inhibits chromatin remodeling to maintain the silenced states of the locus. Biologically, PcG-deficient mice provided biological evidence that PcG are essential for sustaining stem cell activity. More recently PcG were reported to be correlated with cancer progression and prognosis as well as with cancer stem cell activity. PcG may thus play a crucial part in sustaining the activities of malignant as well as normal stem cells. Although PcG were initially seen to maintain stem cell activity through repression of the INK4a locus, they now appear to perform more diverse functions in supporting stem cells. This paper summarizes current information on the molecular roles of PcG in normal and malignant stem cells and discusses the implications in future cancer therapy and regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.