ArticleInternational journal of hematology2008
MLL gene fusions in human leukaemias: in vivo modelling to recapitulate these primary tumourigenic events.
Article in International journal of hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Applications of Genome Editing Technology in Animal Disease Modeling and Gene Therapy.Computational and structural biotechnology journal · 2019Review
- Modeling mixed-lineage-rearranged leukemia initiation in CD34Haematologica · 2017Article
- Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.Cancer science · 2015Article
- Cell context in the control of self-renewal and proliferation regulated by MLL1.Cell cycle (Georgetown, Tex.) · 2013Article
- MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny.Leukemia · 2013Article
- Article
- Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Deregulated transcription factors in leukemia.International journal of hematology · 2011Review
- Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.Nature · 2010Article
- The presence of mature granulocytes/monocytes derived from leukemic cells in MLL-associated leukemia.International journal of hematology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Recurrent reciprocal chromosomal translocations are frequently found in leukaemias and sarcomas as initiating events in these cancers. Mouse models of chromosomal translocations are not only important for the elucidation of the mechanism of these factors underlying the disease but are also important pre-clinical models for assessing new drug combinations, developing new rational therapeutic strategies based on new drugs and testing novel macromolecular drugs. We describe three technologies for creating chromosomal translocation mimics in mice, applied specifically to understand how the MLL-fusions contribute to leukaemia. An important finding of this work is that the lineage of the tumours can be controlled by the MLL-protein fusion. The translocation mimic methods can be applied to any human reciprocal chromosomal translocation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.