ArticleHistochemistry and cell biology2008
Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Sex- and endurance training-mediated cardiovascular protection through lipids during exercise.Trends in endocrinology and metabolism: TEM · 2025Review
- Time-restricted feeding regulates lipid metabolism under metabolic challenges.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- PRMT5 links lipid metabolism to contractile function of skeletal muscles.EMBO reports · 2023Article
- Multitissue responses to exercise: a MoTrPAC feasibility study.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Receptors that bind to PEDF and their therapeutic roles in retinal diseases.Frontiers in endocrinology · 2023Review
- The Regulation of Fat Metabolism During Aerobic Exercise.Biomolecules · 2020Review
- SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice.BMJ open gastroenterology · 2020Article
- Glutathione and Nitric Oxide: Key Team Players in Use and Disuse of Skeletal Muscle.Nutrients · 2019Review
- Of mice and men: The physiological role of adipose triglyceride lipase (ATGL).Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- An aPPARent Functional Consequence in Skeletal Muscle Physiology via Peroxisome Proliferator-Activated Receptors.International journal of molecular sciences · 2018Review
- G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle.Molecular metabolism · 2016Article
- Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response.Oncotarget · 2016Article
- Increases in skeletal muscle ATGL and its inhibitor G0S2 following 8 weeks of endurance training in metabolically different rat skeletal muscles.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity.Journal of diabetes research · 2016Article
- Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice.American journal of physiology. Endocrinology and metabolism · 2015Article
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- Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle.The Journal of physiology · 2013Article
- Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58.Journal of lipid research · 2012Article
- Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells.Biochemistry research international · 2012Article
- Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone.Metabolism: clinical and experimental · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulation of triacylglycerol (TAG) and lipid intermediates in skeletal muscle plays an important role in the etiology of insulin resistance and type 2 diabetes mellitus. Disturbances in skeletal muscle lipid turnover and lipolysis may contribute significantly to this. So far, knowledge on the regulation of muscle lipolysis is limited. Recently the identification of a new lipase was reported: adipose triglyceride lipase (ATGL). ATGL deficient animals show significant lipid accumulation in skeletal muscle, which may indicate that ATGL plays a pivotal role in skeletal muscle lipolysis. However, until now, it is still unknown whether ATGL protein is expressed in human skeletal muscle. Therefore, the aim of the present study was to investigate whether ATGL is expressed at the protein level in human skeletal muscle, and to examine whether its expression is fiber-type specific. To accomplish this, we established an imunohistochemical and immunofluorescent staining procedure to study ATGL protein expression in relation to fiber type in human vastus lateralis muscle of eight male subjects (BMI range: 21.0-34.5 kg/m2 and age: 38-59 years). In the present paper we report for the first time that ATGL protein is indeed expressed in human skeletal muscle. Moreover, ATGL is exclusively expressed in type I (oxidative) muscle fibers, suggesting a pivotal role for ATGL in intramuscular fatty acid handling, lipid storage and breakdown.
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