SynthesisHuman heredity2008
Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium.
Synthesis in Human heredity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Identification of therapeutic targets from genetic association studies using hierarchical component analysis.BioData mining · 2020Article
- The Contribution of Low-Frequency and Rare Coding Variation to Susceptibility to Type 2 Diabetes.Current diabetes reports · 2019Review
- Type 2 diabetes: genetic data sharing to advance complex disease research.Nature reviews. Genetics · 2016Review
- Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes.Nature reviews. Endocrinology · 2016Review
- Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.The Journal of experimental medicine · 2015Article
- ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.Annals of human genetics · 2014Article
- Article
- Evaluating empirical bounds on complex disease genetic architecture.Nature genetics · 2013Article
- Linkage of type 2 diabetes on chromosome 9p24 in Mexican Americans: additional evidence from the Veterans Administration Genetic Epidemiology Study (VAGES).Human heredity · 2013Article
- Identifying plausible genetic models based on association and linkage results: application to type 2 diabetes.Genetic epidemiology · 2012Article
- Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis.Diabetologia · 2012Article
- Who should we target for diabetes prevention and diabetes risk reduction?Current diabetes reports · 2012Review
- The complex interplay of genetic and lifestyle risk factors in type 2 diabetes: an overview.Scientifica · 2012Review
- Replication in genome-wide association studies.Statistical science : a review journal of the Institute of Mathematical Statistics · 2009Article
- Finding common susceptibility variants for complex disease: past, present and future.Briefings in functional genomics & proteomics · 2009Review
- Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies.Diabetologia · 2009Article
- Genome-wide association studies in type 2 diabetes.Current diabetes reports · 2009Review
- Article
- Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study.American journal of human genetics · 2002Article
- A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.American journal of human genetics · 2001Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
backgroundThe International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans.
methodsWe carried out meta-analysis using the genome scan meta-analysis (GSMA) method which divides the genome into bins of approximately 30 cM, ranks the best linkage results in each bin for each sample, and then sums the ranks across samples. We repeated the meta-analysis using 2 cM bins, and/or replacing bin ranks with measures of linkage evidence: bin maximum LOD score or bin minimum p value for bins with p value <0.05 (truncated p value). We also carried out computer simulations to assess the empirical type I error rates of these meta-analysis methods.
resultsOur analyses provided modest evidence for type 2 diabetes-predisposing variants on chromosomes 4, 10, and 14 (using LOD scores or truncated p values), or chromosome 10 and 16 (using ranks). Our simulation results suggested that uneven marker density across studies results in substantial variation in empirical type I error rates for all meta-analysis methods, but that 2 cM bins and scores that make more explicit use of linkage evidence, especially the truncated p values, reduce this problem.
conclusionWe identified regions modestly linked with type 2 diabetes by summarizing results from 23 autosomal genome scans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.