ArticleJournal of biomechanics2008
Combined effects of microtopography and cyclic strain on vascular smooth muscle cell orientation.
Article in Journal of biomechanics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Nuclear and cellular alignment of primary corneal epithelial cells on topography.Journal of biomedical materials research. Part A · 2013Trial
- Native extracellular matrix orientation determines multipotent vascular stem cell proliferation in response to cyclic uniaxial tensile strain and simulated stent indentation.Biochemistry and biophysics reports · 2022Article
- Article
- Collagen-Based Tissue Engineering Strategies for Vascular Medicine.Frontiers in bioengineering and biotechnology · 2019Review
- Potential strain-dependent mechanisms defining matrix alignment in healing tendons.Biomechanics and modeling in mechanobiology · 2018Article
- A Low-Cost Mechanical Stretching Device for Uniaxial Strain of Cells: A Platform for Pedagogy in Mechanobiology.Journal of biomechanical engineering · 2018Article
- Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research.Nano letters · 2018Article
- Article
- Prediction of Cell Alignment on Cyclically Strained Grooved Substrates.Biophysical journal · 2016Article
- Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments.Cellular and molecular bioengineering · 2016Review
- Biomimetic substrate control of cellular mechanotransduction.Biomaterials research · 2016Review
- Magnitude-dependent proliferation and contractility modulation of human bladder smooth muscle cells under physiological stretch.World journal of urology · 2015Article
- Competition between cap and basal actin fiber orientation in cells subjected to contact guidance and cyclic strain.Scientific reports · 2015Article
- The effects of mechanical stimulation on controlling and maintaining marrow stromal cell differentiation into vascular smooth muscle cells.Journal of biomechanical engineering · 2015Article
- Lithography-free fabrication of reconfigurable substrate topography for contact guidance.Biomaterials · 2015Article
- Cell microenvironment engineering and monitoring for tissue engineering and regenerative medicine: the recent advances.BioMed research international · 2014Review
- Influence of extracellular matrix proteins and substratum topography on corneal epithelial cell alignment and migration.Tissue engineering. Part A · 2013Article
- Automated and adaptable quantification of cellular alignment from microscopic images for tissue engineering applications.Tissue engineering. Part C, Methods · 2011Article
- Biophysical regulation of histone acetylation in mesenchymal stem cells.Biophysical journal · 2011Article
- A novel platform for in situ investigation of cells and tissues under mechanical strain.Acta biomaterialia · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cellular alignment studies have shown that cell orientation has a large effect on the expression and behavior of cells. Cyclic strain and substrate microtopography have each been shown to regulate cellular alignment. This study examined the combined effects of these two stimuli on the alignment of bovine vascular smooth muscle cells (VSMCs). Cells were cultured on substrates with microgrooves of varying widths oriented either parallel or perpendicular to the direction of an applied cyclic tensile strain. We found that microgrooves oriented parallel to the direction of the applied strain limited the orientation response of VSMCs to the mechanical stimulus, while grooves perpendicular to the applied strain enhanced cellular alignment. Further, the extent to which parallel grooves limited cell alignment was found to be dependent on the groove width. It was found that for both a small (15microm) and a large (70microm) groove width, cells were better able to reorient in response to the applied strain than for an intermediate groove width (40microm). This study indicates that microtopographical cues modulate the orientation response of VSMCs to cyclic strain. The results suggest that there is a range of microgroove dimensions that is most effective at maintaining the orientation of the cells in the presence of an opposing stimulus induced by cyclic strain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.