ArticleJournal of molecular and cellular cardiology2008
Mobilized bone marrow progenitor cells serve as donors of cytoprotective genes for cardiac repair.
Article in Journal of molecular and cellular cardiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Vaxtherapy, a Multiphase Therapeutic Protocol Approach for Longvax, the COVID-19 Vaccine-Induced Disease: Spike Persistence as the Core Culprit and Its Downstream Effects.Diseases (Basel, Switzerland) · 2025Article
- Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction.Journal of the American Heart Association · 2019Article
- Paracrine effect of CXCR4-overexpressing mesenchymal stem cells on ischemic heart injury.Cell biochemistry and function · 2017Article
- Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Application.Stem cells international · 2017Review
- Regulatory roles of interferon-inducible protein 204 on differentiation and vasculogenic activity of endothelial progenitor cells.Stem cell research & therapy · 2016Article
- Attenuation of teratoma formation by p27 overexpression in induced pluripotent stem cells.Stem cell research & therapy · 2016Article
- Endothelial progenitor cells in cardiovascular diseases: from biomarker to therapeutic agent.Regenerative medicine research · 2013Review
- Revisiting cardiovascular regeneration with bone marrow-derived angiogenic and vasculogenic cells.British journal of pharmacology · 2013Review
- Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF-1 in a rat model.Journal of cellular and molecular medicine · 2012Article
- Adult stem cell mobilization enhances intramembranous bone regeneration: a pilot study.Clinical orthopaedics and related research · 2012Article
- Granulocyte colony-stimulating factor does not enhance recruitment of bone marrow-derived cells in rats with acute myocardial infarction.Experimental and clinical cardiology · 2012Article
- Excitation-contraction coupling in ventricular myocytes is enhanced by paracrine signaling from mesenchymal stem cells.Journal of molecular and cellular cardiology · 2012Article
- Reprogramming of skeletal myoblasts for induction of pluripotency for tumor-free cardiomyogenesis in the infarcted heart.Circulation research · 2011Article
- Cardiac tumorigenic potential of induced pluripotent stem cells in an immunocompetent host with myocardial infarction.Regenerative medicine · 2011Article
- Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival.American journal of physiology. Heart and circulatory physiology · 2010Article
- Granulocyte colony-stimulating factor for ischemic heart failure: should we use it?Heart failure reviews · 2010Review
- Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2010Article
- Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors.Stem cells (Dayton, Ohio) · 2009Article
- Endothelial progenitor cells in neovascularization of infarcted myocardium.Journal of molecular and cellular cardiology · 2008Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
We proposed here that mobilized progenitor cells (MPCs) from the bone marrow are special cell types which carry cytoprotective proteins for cardiac repair following ischemia. Myocardial ischemia was induced by ligation of the left anterior descending coronary artery (LAD) in mice. Progenitor cells in peripheral blood were analyzed by fluorescence-activated cell sorting (FACS). The expression of cytoprotective genes was assayed by ELISA, RT-PCR, and/or real-time PCR. G-CSF was markedly up-regulated in the ischemic myocardium. A good correlation was observed between serum G-CSF and progenitor cells in circulation following LAD ligation. MPCs overexpressed cardiac transcription factor, GATA-4, and anti-apoptotic factor, Bcl-2, besides expression of the surface markers of bone marrow stem cells (BMSCs). Transplantation of cultured MPCs into the ischemic border area significantly improved cardiac function by reducing infarction size. More importantly, MPCs significantly protected cardiomyocytes against apoptosis when co-cultured with cardiomyocytes. The cardiac protection by MPCs was blocked by Bcl-2 neutralizing antibody and GATA-4 siRNA. In contrast, transfection of BMSCs with GATA-4 provided increased protection of myocytes against apoptosis. It is concluded that MPCs are highly cytoprotective and carry protective genes responsible for cardiac repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.