Evidence map›Paper›PMID 18221488›Full record

ReviewFEMS microbiology reviews2008

Histone modifications and chromatin dynamics: a focus on filamentous fungi.

Gerald Brosch, Peter Loidl, Stefan Graessle

Open access · bronzeAbstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 168 citations in OpenAlex.

  1. Article
  2. [Histone deacetylases and alcohol-related liver disease].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Menthone lowers H3K27ac levels to inhibitFrontiers in microbiology · 2025
    Article
  8. Enhanced oxidative stress resistance in Ustilago maydis and its implications on the virulence.International microbiology : the official journal of the Spanish Society for Microbiology · 2024
    Article
  9. Article
  10. Review
  11. Histone MethyltransferaseJournal of fungi (Basel, Switzerland) · 2024
    Article
  12. Article
  13. An ascomycete H4 variant with an unknown function.Royal Society open science · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. The histone code of the fungal genusMicrobial genomics · 2022
    Article
  19. Review
  20. Exposure to theMicrobiology (Reading, England) · 2022
    Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gerald BroschDivision of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Pregl-Strasse 3, Innsbruck, Austria.
Peter Loidl
Stefan Graessle
Innsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide and local changes in gene expression and affect a variety of processes in response to internal and external signals during growth, differentiation, development, in metabolic processes, diseases, and abiotic and biotic stresses. This review aims at summarizing the roles of histone H1 and the acetylation and methylation of histones in filamentous fungi and links this knowledge to the huge body of data from other systems. Filamentous fungi show a wide range of morphologies and have developed a complex network of genes that enables them to use a great variety of substrates. This fact, together with the possibility of simple and quick genetic manipulation, highlights these organisms as model systems for the investigation of gene regulation. However, little is still known about regulation at the chromatin level in filamentous fungi. Understanding the role of chromatin in transcriptional regulation would be of utmost importance with respect to the impact of filamentous fungi in human diseases and agriculture. The synthesis of compounds (antibiotics, immunosuppressants, toxins, and compounds with adverse effects) is also likely to be regulated at the chromatin level.

Indexed as

Chromatin Assembly and DisassemblyAcetylationChromatinDNA MethylationFungal ProteinsFungiGene Expression Regulation, FungalHistonesHumansPhylogenyProtein Structure, TertiaryChromatinFungal ProteinsHistones

Identifiers

PMID18221488
PMCPMC2442719
OpenAlexW1935731310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.