ArticleAging cell2008
Drosophila lifespan control by dietary restriction independent of insulin-like signaling.
Article in Aging cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
107 citing papers in PubMed, 189 citations in OpenAlex.
- Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species.Frontiers in genetics · 2026Review
- Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations ofEvolution letters · 2025Article
- Effects of sodium selenite, yeast selenium, and nano-selenium on toxicity, growth, and selenium bioaccumulation in Lucilia sericata maggots.Environmental science and pollution research international · 2024Article
- Combinatorial interventions in aging.Nature aging · 2023Review
- The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective.Biomolecules · 2023Review
- The landscape of aging.Science China. Life sciences · 2022Review
- Amino Acid Availability Is Not Essential for Life-Span Extension by Dietary Restriction in the Fly.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression.Cellular and molecular life sciences : CMLS · 2022Review
- A mini-screen to identify the role of microRNAs in the Drosophila Insulin-Producing cells regulating lifespan.microPublication biology · 2022Article
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- The seesaw of diet restriction and lifespan: lessons from Drosophila studies.Biogerontology · 2021Article
- The relationship between longevity and diet is genotype dependent and sensitive to desiccation inThe Journal of experimental biology · 2020Article
- Aging mechanisms-A perspective mostly fromAdvanced genetics (Hoboken, N.J.) · 2020Article
- Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling.BMC biology · 2020Article
- Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms.Nutrients · 2020Review
- Methionyl-tRNA Synthetase Regulates Lifespan inMolecules and cells · 2020Article
- Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population.BMC genomics · 2020Article
- The Phosphatase CSW Controls Life Span by Insulin Signaling and Metabolism Throughout Adult Life inFrontiers in genetics · 2020Article
- Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction.Cells · 2019Review
- Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides.Journal of insect physiology · 2019Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Reduced insulin/insulin-like growth factor (IGF) signaling may be a natural way for the reduction of dietary nutrients to extend lifespan. While evidence challenging this hypothesis is accumulating with Caenorhabditis elegans, for Drosophila melanogaster it is still thought that insulin/IGF and the mechanisms of dietary restriction (DR) might as yet function through overlapping mechanisms. Here, we aim to understand this potential overlap. We found that over-expression of dFOXO in head fat body extends lifespan and reduces steady-state mRNA abundance of insulin-like peptide-2 under conditions of high dietary yeast, but not when yeast is limiting. In contrast, conditions of DR that increase lifespan change only insulin-like peptide-5 (ilp5) mRNA abundance. Thus, reduction of ilp5 mRNA is associated with longevity extension by DR, while reduction of insulin-like peptide-2 is associated with the diet-dependent effects of FOXO over-expression upon lifespan. To assess whether reduction of ilp5 is required for DR to extend lifespan, we blocked its diet-dependent change with RNAi. Loss of the ilp5 dietary response did not diminish the capacity of DR to extend lifespan. Finally, we assessed the capacity of DR to extend lifespan in the absence of dFOXO, the insulin/IGF-responsive transcription factor. As with the knockdown of ilp5 diet responsiveness, DR was equally effective among genotypes with and without dFOXO. It is clear from many Drosophila studies that insulin/IGF mediates growth and metabolic responses to nutrition, but we now find no evidence that this endocrine system mediates the interaction between dietary yeast and longevity extension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.