ArticleThe journal of sexual medicine2008
Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.
Article in The journal of sexual medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats.Journal of cellular and molecular medicine · 2020Article
- The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation.Scientific reports · 2019Article
- Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors.European journal of drug metabolism and pharmacokinetics · 2017Review
- Role of Adenosine Receptor(s) in the Control of Vascular Tone in the Mouse Pudendal Artery.The Journal of pharmacology and experimental therapeutics · 2016Article
- GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span.Endocrinology · 2013Article
- Purinergic signalling and diabetes.Purinergic signalling · 2013Review
- Article
- Erectile dysfunction in young non-obese type II diabetic Goto-Kakizaki rats is associated with decreased eNOS phosphorylation at Ser1177.The journal of sexual medicine · 2010Article
- Role of adenosine signaling in penile erection and erectile disorders.The journal of sexual medicine · 2010Review
- Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism.The journal of sexual medicine · 2010Article
- Diabetes, obesity and erectile dysfunction: field overview and research priorities.The Journal of urology · 2009Review
- TNF-alpha infusion impairs corpora cavernosa reactivity.The journal of sexual medicine · 2009Article
- Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium.Journal of the American Society of Hypertension : JASH · 2008Article
- Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Animal models of erectile dysfunction (ED): potential utility of non-human primates as a model of atherosclerosis-induced vascular ED.International journal of impotence researchReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
introductionErectile dysfunction (ED) in diabetes is associated with autonomic neuropathy and endothelial dysfunction. Whereas the nonadrenergic-noncholinergic (NANC)/neurogenic nitric oxide pathway has received great attention in diabetes-associated ED, few studies have addressed sympathetic overactivity.
aimTo test the hypothesis that adenosine-induced inhibition of adrenergic-mediated contractile responses in mouse corpus cavernosum is impaired in the presence of diabetes.
methodsThe db/db (obesity and type II diabetes caused by a leptin receptor mutation) mouse strain was used as a model of obesity and type II diabetes, and standard procedures were performed to evaluate functional cavernosal responses.
main outcome measuresIncreased cavernosal responses to sympathetic stimulation in db/db mice are not associated with impaired prejunctional actions of adenosine.
resultsElectrical field stimulation (EFS)-, but not phenylephrine (PE)-, induced contractions are enhanced in cavernosal strips from db/db mice in comparison with those from lean littermates. Direct effects of adenosine, 2-chloro-adenosine, A(1) receptor agonist C-8031 (N6 cyclopentyladenosine), and sodium nitroprusside are similar between the strips from lean and db/db mice, whereas relaxant responses to acetylcholine and NANC stimulation are significantly impaired in the cavernosal strips from db/db mice. 5'-Iodotubercidin (adenosine kinase inhibitor) and dipyridamole (inhibitor of adenosine transport), as well as the A(1) agonist C-8031, significantly and similarly inhibit contractions induced by stimulation of adrenergic nerves in the cavernosal strips from lean and db/db mice.
conclusionsResults from this study suggest that corpora cavernosa from obese and diabetic db/db mice display altered neural-mediated responses that would favor penile detumescence, i.e., increased contractile response to adrenergic nerve stimulation and decreased relaxant responses upon activation of NANC nerves. However, increased cavernosal responses to adrenergic nerve stimulation are not due to impaired negative modulation of sympathetic neurotransmission by adenosine in this diabetic model.
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