ReviewAnti-cancer agents in medicinal chemistry2008
Biological modulation by lectins and their ligands in tumor progression and metastasis.
Review in Anti-cancer agents in medicinal chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- A systematic review of multimodal clinical biomarkers in the management of thyroid eye disease.Reviews in endocrine & metabolic disorders · 2022Pooled it
- Developing immunotherapies through glycosylation reprogramming to combat solid cancers.Frontiers in immunology · 2026Review
- 1-Deoxynojirimycin Derivative Containing Tegafur Induced HCT-116 Cell Apoptosis through Mitochondrial Dysfunction and Oxidative Stress Pathway.ACS medicinal chemistry letters · 2024Article
- Review
- Article
- Development of Galectin-3 Targeting Drugs for Therapeutic Applications in Various Diseases.International journal of molecular sciences · 2023Review
- Article
- Glycosylation as a regulator of site-specific metastasis.Cancer metastasis reviews · 2022Review
- Lactosyl-sepharose binding proteins from pancreatic cancer cells show differential expression in primary and metastatic organs.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- HO-1 Interactors Involved in the Colonization of the Bone Niche: Role of ANXA2 in Prostate Cancer Progression.Biomolecules · 2020Article
- Defining the Specificity of Carbohydrate-Protein Interactions by Quantifying Functional Group Contributions.Journal of chemical information and modeling · 2018Article
- Role of Galectins in Tumors and in Clinical Immunotherapy.International journal of molecular sciences · 2018Review
- Complex effects of tumor microenvironment on the tumor disposition of carrier-mediated agents.Nanomedicine (London, England) · 2017Review
- Structural analysis and unique molecular recognition properties of a Bauhinia forficata lectin that inhibits cancer cell growth.The FEBS journal · 2017Article
- Synthetic glycoconjugates inhibitors of tumor-related galectin-3: an update.Glycoconjugate journal · 2016Review
- Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules.Chemical science · 2016Article
- The Sweet Side of Immune Evasion: Role of Glycans in the Mechanisms of Cancer Progression.Frontiers in oncology · 2016Review
- Significance of β-Galactoside α2,6 Sialyltranferase 1 in Cancers.Molecules (Basel, Switzerland) · 2015Review
- Lectins with potential for anti-cancer therapy.Molecules (Basel, Switzerland) · 2015Review
- Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lectins are a group of specific proteins that preferentially bind to carbohydrates inside and outside cells. To date, an increasing number of animal lectins have been found and categorized into several families in terms of the significant primary structural homology, while the classification is not always straightforward. These lectins can exert immense biological functions mainly through their specific carbohydrate-protein interactions in a variety of situations. In cancer biology, aberrant glycosylation changes on many glycoproteins and glycolipids are often observed and numerous experimental evidences have revealed that these structural changes are related to tumor malignancy. Galectins, which are broadly expressed animal lectins, can play crucial biological roles in tumor cell-cell or cell-matrix interactions through their binding activities to the tumor cell surface carbohydrate determinants. Certain galectin family proteins have also shown to affect tumor cell survival, signal transduction, and proliferation mainly inside the cell. Selectins, which are one of the C-type lectins and expressed leukocytes and/or vascular endothelium, can also play an immense role in tumor cell adhesion and invasion. In addition, certain annexin family proteins, which are originally known as phospholipid binding proteins, have been revealed to possess the carbohydrate binding activity, and these novel functions in tumors are being unveiled. Understanding how carbohydrate-protein interactions function in tumor cells will be one of the important goals in cancer research. This review focuses on the role of these lectins and their ligands in cancer progression and metastasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.