ArticlePediatric pulmonology2008
Premorbid factors and outcome associated with respiratory virus infections in a pediatric intensive care unit.
Article in Pediatric pulmonology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Hospital utilization rates for influenza and RSV: a novel approach and critical assessment.Population health metrics · 2021Pooled it
- The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis.Influenza and other respiratory viruses · 2016Pooled it
- Clinical characteristics and prognosis of paediatric respiratory syncytial virus-related encephalopathy.Italian journal of pediatrics · 2024Article
- Occurrence of Central Nervous System Complications of Respiratory Syncytial Virus Infections: A Systematic Review with Meta-Analysis.Epidemiologia (Basel, Switzerland) · 2024Review
- Impact of Nirsevimab Immunization on Pediatric Hospitalization Rates: A Systematic Review and Meta-Analysis (2024).Vaccines · 2024Review
- COVID-19 Associated Croup.Current pediatric reviews · 2024Article
- The Effect of the SARS-CoV-2 Pandemic on Presentation with Diabetic Ketoacidosis in Children with New Onset Type 1 Diabetes MellitusJournal of clinical research in pediatric endocrinology · 2023Article
- Respiratory Syncytial Virus: An Uncommon Cause of Febrile Seizures-Results from a Systematic Review and Meta-Analysis.Pediatric reports · 2022Review
- Mortality in children hospitalised with respiratory syncytial virus infection in Singapore.Singapore medical journal · 2021Article
- Review
- Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Outcome of Encephalitis in Pediatric Intensive Care Unit.Indian journal of pediatrics · 2016Article
- Typical or atypical pneumonia and severe acute respiratory symptoms in PICU.The clinical respiratory journal · 2015Article
- Article
- Article
- Prolonged non-survival in PICU: does a do-not-attempt-resuscitation order matter.BMC anesthesiology · 2013Article
- A literature review and survey of childhood pneumonia etiology studies: 2000-2010.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Review
- Megapneumonia Coinfection: pneumococcus, Mycoplasma pneumoniae, and Metapneumovirus.Case reports in medicine · 2012Article
- Childhood pneumococcal diseases and serotypes: can vaccines protect?Indian journal of pediatrics · 2010Article
- Influenza and parainfluenza associated pediatric ICU morbidity.Indian journal of pediatrics · 2010Article
Corrections and comments
- Erratum issuedHung, Erica [corrected to Leung, Erica]
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to report the clinical features and outcome of all children with a laboratory proven diagnosis of respiratory virus infection admitted to a university Pediatric Intensive Care Unit (PICU).
methodsRetrospective study between January 2003 and April 2007 was carried out in the PICU. Every child with a laboratory-confirmed viral infection was included.
results54 viruses were identified in 49 children (27 M, 22 F) over a 52-month period. The three respiratory virus species, respiratory syncytial virus (RSV) (n = 17), influenza (n = 13) and parainfluenza (n = 12), accounted for 86% of these 49 cases. PICU admissions due to influenza A (n = 10) were more common than influenza B (n = 3), whereas parainfluenza type 3 (n = 7) was the commonest subtype of parainfluenza infection. Comparing these three common viruses, the mean age of children admitted with RSV was lower than with influenza or parainfluenza (1.2 years vs. 5.6 years vs. 2.4 years, P = 0.003). Pre-existing conditions such as prematurity and chronic lung disease were only present in children with RSV infection. These respiratory viruses caused both upper (croup) and lower respiratory tract diseases (bronchiolitis, pneumonia). Extrapulmonary presentations were less prevalent and included encephalitis, seizures, cardiac arrest, coexisting diabetes ketoacidosis and acute lymphoblastic leukemia. One patient with RSV and another with influenza A died during their PICU stay. Nearly half of these patients required ventilatory support or received systemic corticosteroids, and 88% received initial broad spectrum antibiotic coverage. Approximately one in five of them had nebulised adrenaline, airway endoscopies or bacterial co-infections. Adenovirus was isolated in four patients and two (both with adenovirus type 3) died during the PICU stay.
conclusionsIn PICU, respiratory viral infections were associated with significant morbidity and life-threatening conditions.
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