Evidence map›Paper›PMID 18219596›Full record

ReviewMolecular biotechnology2008

In silico characterization of proteins: UniProt, InterPro and Integr8.

Nicola Jane Mulder, Paul Kersey, Manuela Pruess, Rolf Apweiler

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Mutation ofAntibiotics (Basel, Switzerland) · 2025
    Article
  3. Article
  4. The Role of theMicroorganisms · 2023
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Male-specific region of the bovine Y chromosome is gene rich with a high transcriptomic activity in testis development.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  11. Article
  12. Article
  13. In silico prediction of antimalarial drug target candidates.International journal for parasitology. Drugs and drug resistance · 2012
    Article
  14. The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Bioinformatics and molecular modeling in glycobiology.Cellular and molecular life sciences : CMLS · 2010
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicola Jane MulderEMBL Outstation - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. mulder@ebi.ac.uk
Paul Kersey
Manuela Pruess
Rolf Apweiler

Funding

NHGRI NIH HHS 1R01HG02273-01NHGRI NIH HHS 1 U01 HG02712-01PHS HHS CABIGICR-10-10-01PHS HHS HHSN266200400 061CPHS HHS ITR-0205470
6 · The paper itself

Abstract

Nucleic acid sequences from genome sequencing projects are submitted as raw data, from which biologists attempt to elucidate the function of the predicted gene products. The protein sequences are stored in public databases, such as the UniProt Knowledgebase (UniProtKB), where curators try to add predicted and experimental functional information. Protein function prediction can be done using sequence similarity searches, but an alternative approach is to use protein signatures, which classify proteins into families and domains. The major protein signature databases are available through the integrated InterPro database, which provides a classification of UniProtKB sequences. As well as characterization of proteins through protein families, many researchers are interested in analyzing the complete set of proteins from a genome (i.e. the proteome), and there are databases and resources that provide non-redundant proteome sets and analyses of proteins from organisms with completely sequenced genomes. This article reviews the tools and resources available on the web for single and large-scale protein characterization and whole proteome analysis.

Indexed as

Databases, ProteinAmino Acid SequenceComputational BiologyGenomeHumansProteinsProteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.