Evidence map›Paper›PMID 18219392›Full record

ArticleThe Journal of clinical investigation2008

Can you hear me now? A genetic model of otitis media with effusion.

Evelyn Lazaridis, James C Saunders

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Evelyn LazaridisDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. elaz@mail.med.upenn.edu
James C Saunders
University of Pennsylvania · US

Funding

HAIR CELL PATHOPHYSIOLOGYR01DC000710 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI SAUNDERS, JAMES C · 1990 to 2006
$1.9M
Training in the Neurobiology of OtorhinolaryngologyT32DC005363 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI SAUNDERS, JAMES C · 2003 to 2007
$1.5M
NIDCD NIH HHS DC000710NIDCD NIH HHS DC005363NIDCD NIH HHS R01 DC000710NIDCD NIH HHS T32 DC005363
6 · The paper itself

Abstract

Otitis media with effusion (OME) is characterized by the occurrence of fluid in the middle-ear cavity in the absence of any signs of acute ear infection and occurs most frequently in children with auditory or eustachian tube dysfunction. Its chronic form is an important clinical issue for pediatricians and otologists alike. The study by Depreux et al. in this issue of the JCI shows that absence of the transcriptional activator Eya4 in knockout mice results in abnormal structuring of the eustachian tube, thus predisposing these animals to OME (see the related article beginning on page 651). The development of this genetics-based animal model is an important advance for understanding OME and for exploring new avenues of treatment.

Indexed as

Models, GeneticAnimalsDisease Models, AnimalEar, MiddleHearing Loss, SensorineuralHumansMiceMice, KnockoutOtitis Media with EffusionTrans-ActivatorsEya4 protein, mouseTrans-Activators

Identifiers

PMID18219392
PMCPMC2213373
OpenAlexW2089113425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.