Evidence map›Paper›PMID 18219083›Full record

ArticleThe Indian journal of medical research2007

Clinical features & risk factors associated with cryptosporidiosis in HIV infected adults in India.

S S Rao Ajjampur, J R Asirvatham, Dheepa Muthusamy, B P Gladstone, O C M Abraham, Dilip Mathai, Honorine Ward, Christine Wanke, Gagandeep Kang

Open access · greenAbstract read
In one paragraph

Article in The Indian journal of medical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. First Molecular Characterization ofPathogens (Basel, Switzerland) · 2021
    Article
  3. Open access Macedonian journal of medical sciences · 2019
    Article
  4. Gastroenterology and hepatology from bed to bench · 2017
    Article
  5. Article
  6. Article
  7. Intestinal protozoans in adults with diarrhea.North American journal of medical sciences · 2013
    Article
  8. Article
  9. Article
  10. Cryptosporidiosis: environmental, therapeutic, and preventive challenges.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

S S Rao AjjampurDepartment of Gastrointestinal Sciences, Christian Medical College Vellore,India.
J R Asirvatham
Dheepa Muthusamy
B P Gladstone
O C M Abraham
Dilip Mathai
Honorine Ward
Christine Wanke
Gagandeep Kang
Christian Medical College & Hospital · IN

Funding

Miriam/Brown/Tufts Fogarty AIDS International Training and Research ProgramD43TW000237 · FIC · MIRIAM HOSPITAL · PI CU-UVIN, SUSAN · 1993 to 2014
$10.6M
Multi-disciplinary research training in enteric infectionsD43TW007392 · FIC · CHRISTIAN MEDICAL COLLEGE · PI KANG, GAGANDEEP · 2005 to 2020
$2.9M
FIC NIH HHS D43 TW000237FIC NIH HHS D43TW00237FIC NIH HHS D43 TW007392
6 · The paper itself

Abstract

BACKGROUND &

objectiveCryptosporidiosis is a leading cause of protracted, life threatening diarrhoea in HIV infected patients. Although data on prevalence are available for Indian patients, no information on risk factors for transmission exists. We therefore undertook this study to identify risk factors for transmission of cryptosporidiosis in HIV infected adults.

methodsBoth symptomatic (diarrhoeal) and asymptomatic HIV infected patients were screened for cryptosporidiosis. All Cryptosporidium spp. positive cases were enrolled in the study and interviewed to record socio-demographic information, water supply and animal contact. Data were analysed to study clinical features and potential association with species and genotype.

resultsOf the 28 cryptosporidial infections identified on screening 111 HIV positive patients with diarrhoea, 10 (35.7%) had chronic diarrhoea, 14 (50%) had associated fever and 8 (28.6%) had nausea. Symptomatic patients had a significantly higher number of co-infections with other enteric parasites (P=0.04) than 20 asymptomatics of 423 HIV positive individuals screened. Eleven of 17 (64%) patients with potentially zoonotic infections had diarrhoea. Patients with zoonotic species (64%) also tended to have fever more frequently than those infected with C. hominis (58%). Association between area of residence, rural or urban, water source and contact with animals and acquisition of cryptosporidiosis was not statistically significant. INTERPRETATION &

conclusionCryptosporidiosis is an important cause of morbidity in HIV infected individuals in India, resulting in chronic diarrhoea. Risk factors for potentially zoonotic transmission of cryptosporidiosis were described in this study, but larger studies need to be done for a clearer understanding of the transmission dynamics of different cryptosporidial species in developing countries.

Indexed as

AdultAIDS-Related Opportunistic InfectionsAnimalsCryptosporidiosisCryptosporidiumDiarrheaFemaleHumansIndiaMaleMiddle AgedRisk FactorsRural PopulationUrban PopulationWaterWater

Identifiers

PMID18219083
PMCPMC2673507
OpenAlexW2154875700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.