ArticlePlant physiology2008
Cloning and characterization of naringenin 8-prenyltransferase, a flavonoid-specific prenyltransferase of Sophora flavescens.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 135 citations in OpenAlex.
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- Naturally occurring prenylated flavonoids from AfricanRSC advances · 2025Review
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- Catalytic mechanism underlying the regiospecificity of coumarin-substrate transmembrane prenyltransferases in Apiaceae.Plant & cell physiology · 2025Article
- Molecular Cloning and Functional Identification of a Pericarp- and Testa-Abundant Gene's (International journal of molecular sciences · 2024Article
- Polyphenols and Phenolic Glucosides in Antibacterial Twig Extracts of Naturally OccurringPharmaceutics · 2024Article
- Regiodivergent biosynthesis of bridged bicyclononanes.Nature communications · 2024Article
- Prenylated Flavonoids of the Moraceae Family: A Comprehensive Review of Their Biological Activities.Plants (Basel, Switzerland) · 2024Review
- Phytochemistry and pharmacology of natural prenylated flavonoids.Archives of pharmacal research · 2023Review
- Diprenylated cyclodipeptide production by changing the prenylation sequence of the nature's synthetic machinery.Applied microbiology and biotechnology · 2023Article
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- Heterologous biosynthesis of isobavachalcone in tobacco based onFrontiers in plant science · 2022Article
- Synthetic production of prenylated naringenins in yeast using promiscuous microbial prenyltransferases.Metabolic engineering communications · 2021Article
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- A Cytosol-Localized Geranyl Diphosphate Synthase fromPlant physiology · 2020Article
- Production of Prenylated Stilbenoids in Hairy Root Cultures of Peanut (Molecules (Basel, Switzerland) · 2020Article
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- Toward Developing a Yeast Cell Factory for the Production of Prenylated Flavonoids.Journal of agricultural and food chemistry · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenylated flavonoids are natural compounds that often represent the active components in various medicinal plants and exhibit beneficial effects on human health. Prenylated flavonoids are hybrid products composed of a flavonoid core mainly attached to either 5-carbon (dimethylallyl) or 10-carbon (geranyl) prenyl groups derived from isoprenoid (terpenoid) metabolism, and the prenyl groups are crucial for their biological activity. Prenylation reactions in vivo are crucial coupling processes of two major metabolic pathways, the shikimate-acetate and isoprenoid pathways, in which these reactions are also known as a rate-limiting step. However, none of the genes responsible for the prenylation of flavonoids has been identified despite more than 30 years of research in this field. We have isolated a prenyltransferase gene from Sophora flavescens, SfN8DT-1, responsible for the prenylation of the flavonoid naringenin at the 8-position, which is specific for flavanones and dimethylallyl diphosphate as substrates. Phylogenetic analysis shows that SfN8DT-1 has the same evolutionary origin as prenyltransferases for vitamin E and plastoquinone. The gene expression of SfN8DT-1 is strictly limited to the root bark where prenylated flavonoids are solely accumulated in planta. The ectopic expression of SfN8DT-1 in Arabidopsis thaliana resulted in the formation of prenylated apigenin, quercetin, and kaempferol, as well as 8-prenylnaringenin. SfN8DT-1 represents the first flavonoid-specific prenyltransferase identified in plants and paves the way for the identification and characterization of further genes responsible for the production of this large and important class of secondary metabolites.
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