ReviewMolecular endocrinology (Baltimore, Md.)2008
Welcoming beta-catenin to the gonadotropin-releasing hormone transcriptional network in gonadotropes.
Review in Molecular endocrinology (Baltimore, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Homozygous CDH2 variant may be associated with hypopituitarism without neurological disorders.Endocrine connections · 2023Article
- Exogenous gonadotropin-releasing hormone counteracts the adverse effect of scrotal insulation on testicular functions in bucks.Scientific reports · 2022Article
- Transcriptomic and Histopathological Effects of Bifenthrin to the Brain of Juvenile Rainbow Trout (Toxics · 2021Article
- GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors.International journal of molecular sciences · 2019Article
- GnRH-A Key Regulator of FSH.Endocrinology · 2019Review
- Characterization of the dynamic change of microRNA expression in mice hypothalamus during the time of female puberty.Genes & genomics · 2018Article
- The F0F1 ATP Synthase Complex Localizes to Membrane Rafts in Gonadotrope Cells.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?Molecular endocrinology (Baltimore, Md.) · 2015Review
- Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.The Journal of biological chemistry · 2015Article
- Article
- Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH.Molecular endocrinology (Baltimore, Md.) · 2013Article
- The Lipid Transfer Protein StarD7: Structure, Function, and Regulation.International journal of molecular sciences · 2013Article
- Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation.Endocrine-related cancer · 2013Article
- β-catenin regulates GnRH-induced FSHβ gene expression.Molecular endocrinology (Baltimore, Md.) · 2013Article
- GnRH regulation of Jun and Atf3 requires calcium, calcineurin, and NFAT.Molecular endocrinology (Baltimore, Md.) · 2012Article
- ERK signaling, but not c-Raf, is required for gonadotropin-releasing hormone (GnRH)-induced regulation of Nur77 in pituitary gonadotropes.Endocrinology · 2012Article
- Cold-shock-domain protein A (CSDA) contributes posttranscriptionally to gonadotropin-releasing hormone-regulated expression of Egr1 and indirectly to Lhb.Biology of reproduction · 2012Article
- Potential role of a navigator gene NAV3 in colorectal cancer.British journal of cancer · 2012Article
- StarD7 gene expression in trophoblast cells: contribution of SF-1 and Wnt-beta-catenin signaling.Molecular endocrinology (Baltimore, Md.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GnRH binds its G-coupled protein receptor, GnRHR, on pituitary gonadotropes and stimulates transcription of Cga, Lhb, and Fshb. These three genes encode two heterodimeric glycoprotein hormones, LH and FSH, that act as gonadotropins by regulating gametogenesis and steroidogenesis in both the testes and ovary. GnRH also regulates transcription of Gnrhr. Thus, regulated expression of Cga, Lhb, Fshb, and Gnrhr provides a genomic signature unique to functional gonadotropes. Steadily increasing evidence now indicates that GnRH regulates transcription of its four signature genes indirectly through a hierarchical transcriptional network that includes distinct subclasses of DNA-binding proteins that comprise the immediate early gene (IEG) family. These IEGs, in turn, confer hormonal responsiveness to the four signature genes. Although the IEGs confer responsiveness to GnRH, they cannot act alone. Instead, additional DNA-binding proteins, including the orphan nuclear receptor steroidogenic factor 1, act permissively to allow the four signature genes to respond to GnRH-induced changes in IEG levels. Emerging new findings now indicate that beta-catenin, a transcriptional coactivator and member of the canonical WNT signaling pathway, also plays an essential role in transducing the GnRH signal by interacting with multiple DNA-binding proteins in gonadotropes. Herein we propose that these interactions with beta-catenin define a multicomponent transcriptional network required for regulated expression of the four signature genes of the gonadotrope, Cga, Lhb, Fshb, and Gnrhr.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.