ArticleThe Journal of physiology2008
Decreased activity of the smooth muscle Na+/Ca2+ exchanger impairs arteriolar myogenic reactivity.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Role of the endothelial reverse mode sodium-calcium exchanger in the dilation of the rat middle cerebral artery during hypoosmotic hyponatremia.Pflugers Archiv : European journal of physiology · 2023Article
- Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with NaLaboratory investigation; a journal of technical methods and pathology · 2022Article
- The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells.Comprehensive Physiology · 2021Article
- NaAmerican journal of physiology. Heart and circulatory physiology · 2019Article
- TRPV4 Complexes With the NaFrontiers in physiology · 2019Article
- Contribution of elevated intracellular calcium to pulmonary arterial myocyte alkalinization during chronic hypoxia.Pulmonary circulation · 2016Article
- Hydrophobic bile acids relax rat detrusor contraction via inhibiting the opening of the Na⁺/Ca²⁺ exchanger.Scientific reports · 2016Article
- Arterial α2-Na+ pump expression influences blood pressure: lessons from novel, genetically engineered smooth muscle-specific α2 mice.American journal of physiology. Heart and circulatory physiology · 2015Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Conditional knockout of smooth muscle sodium calcium exchanger type-1 lowers blood pressure and attenuates Angiotensin II-salt hypertension.Physiological reports · 2015Article
- Mechanisms underlying regional differences in the Ca2+ sensitivity of BK(Ca) current in arteriolar smooth muscle.The Journal of physiology · 2013Article
- Attenuated renal vascular responses to acute angiotensin II infusion in smooth muscle-specific Na+/Ca2+ exchanger knockout mice.American journal of physiology. Renal physiology · 2011Article
- Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.PloS one · 2011Article
- Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves.The Journal of physiology · 2010Article
- Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.Diabetes · 2010Article
- Sympathetic nerves and the endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries.American journal of physiology. Heart and circulatory physiology · 2010Article
- Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure.American journal of physiology. Heart and circulatory physiology · 2010Article
- Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles.Hypertension (Dallas, Tex. : 1979) · 2009Article
- New insights in the contribution of voltage-gated Na(v) channels to rat aorta contraction.PloS one · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arteriolar myogenic vasoconstriction occurs when stretch or increased membrane tension leads to smooth muscle cell (SMC) depolarization and opening of voltage-gated Ca(2+) channels. While the mechanism underlying the depolarization is uncertain a role for non-selective cation channels has been demonstrated. As such channels may be expected to pass Na(+), we hypothesized that reverse mode Na(+)/Ca(2+) exchange (NCX) may act to remove Na(+) and in addition play a role in myogenic signalling through coupled Ca(2+) entry. Further, reverse (Ca(2+) entry) mode function of the NCX is favoured by the membrane potential found in myogenically active arterioles. All experiments were performed on isolated rat cremaster muscle first order arterioles (passive diameter approximately 150 mum) which were pressurized in the absence of intraluminal flow. Reduction of extracellular Na(+) to promote reverse-mode NCX activity caused significant, concentration-dependent vasoconstriction and increased intracellular Ca(2+). This vasoconstriction was attenuated by the NCX inhibitors KB-R7943 and SEA 04000. Western blotting confirmed the existence of NCX protein while real-time PCR studies demonstrated that the major isoform expressed in the arteriolar wall was NCX1. Oligonucleotide knockdown (24 and 36 h) of NCX inhibited the vasoconstrictor response to reduced extracellular Na(+) while also impairing both steady-state myogenic responses (as shown by pressure-diameter relationships) and acute reactivity to a 50 to 120 mmHg pressure step. The data are consistent with reverse mode activity of the NCX in arterioles and a contribution of this exchanger to myogenic vasoconstriction.
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Registered trials
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