ArticleBMC medical genetics2008
FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs.
Article in BMC medical genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Impact of fat mass and obesity-associated (FTO) gene variants on adult obesity and overweight: a comprehensive meta-analysis.BMC endocrine disorders · 2026Pooled it
- Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis.Diabetologia · 2012Pooled it
- FTO gene polymorphisms and obesity risk: a meta-analysis.BMC medicine · 2011Pooled it
- Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.BMC medical genetics · 2009Pooled it
- VAREANT: a bioinformatics application for gene variant reduction and annotation.Bioinformatics advances · 2025Article
- Article
- Association between FTO gene polymorphism and obesity in down syndrome children.European journal of pediatrics · 2024Article
- The Role of FTO Risk Haplotype in Overweight/Obesity and Lipid Parameters-Results From the Central China Population Study.International journal of endocrinology · 2024Article
- Article
- m6A demethylase FTO and osteoporosis: potential therapeutic interventions.Frontiers in cell and developmental biology · 2023Review
- The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells.RNA biology · 2022Article
- Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort.PloS one · 2022Article
- Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders.Genes & diseases · 2022Review
- A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severity.iScience · 2021Article
- Differences in brain structure and function in children with theObesity science & practice · 2020Article
- A Comprehensive Genome-Wide and Phenome-Wide Examination of BMI and Obesity in a Northern Nevadan Cohort.G3 (Bethesda, Md.) · 2020Article
- Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population.Genetics and molecular biology · 2020Article
- Association of FTO common variant (rs9939609) with body fat in Turkish individuals.Lipids in health and disease · 2019Article
- Assessment of the FTO gene polymorphisms (rs1421085, rs17817449 and rs9939609) in exercise-trained men and women: the effects of a 4-week hypocaloric diet.Journal of the International Society of Sports Nutrition · 2019Article
- Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine.BMC medical genetics · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFTO is a gene located in chromosome region 16q12.2. Recently two studies have found associations of several single nucleotide polymorphisms (SNPs) in FTO with body mass index (BMI) and obesity, particularly rs1421085, rs17817449, and rs9939609.
methodsWe examined these three SNPs in 583 extremely obese women with current BMI greater than 35 kg/m2 and lifetime BMI greater than 40 kg/m2, and 544 controls who were currently normal weight (BMI<25 kg/m2) and had never been overweight during their lifetimes.
resultsWe detected highly significant associations of obesity with alleles in all three SNPs (p < 10-9). The strongest association was with rs1421085 (p = 3.04 x 10-10, OR = 1.75, CI = 1.47-2.08). A subset of 99 cases had extremely discordant sisters with BMI<25 kg/m2. The discordant sisters differed in allele and genotype frequencies in parallel with the overall case and control sample. The strongest association was with rs17817449 (z = 3.57, p = 3.6 x 10-4).
conclusionThese results suggest common variability in FTO is associated with increased obesity risk or resistance and may in part account for differences between closely related individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.