ArticleGenome biology2008
Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
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Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it, 228 citations in OpenAlex.
- BioprospectingFrontiers in fungal biology · 2021Pooled it
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- Genomic features and the transcriptional regulation of secondary metabolite biosynthesis of endophytic fungusMicrobial genomics · 2026Article
- Exploring the potential of Bacillus spp. for secondary metabolite production through genome mining approaches.Journal, genetic engineering & biotechnology · 2025Article
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- Comparative genomics of Vibrio toranzoniae strains.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Six type-I PKS classes and highly conserved melanin and elsinochrome gene clusters found in diverse Elsinoë species.BMC genomics · 2024Article
- Comparative genomics of Metarhizium brunneum strains V275 and ARSEF 4556: unraveling intraspecies diversity.G3 (Bethesda, Md.) · 2024Article
- The ACE1 secondary metabolite gene cluster is a pathogenicity factor of wheat blast fungus.Communications biology · 2024Article
- Comparative genomics of Vibrio toranzoniae strains.Research square · 2024Article
- Comprehensive analysis of genomic variation, pan-genome and biosynthetic potential of Corynebacterium glutamicum strains.PloS one · 2024Article
- Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure.Journal of the American Chemical Society · 2023Article
- Cocoa-associated filamentous fungi for the biocontrol of aflatoxigenic Aspergillus flavus.Journal of basic microbiology · 2023Article
- Horizontally Transferred DNA in the Genome of the Fungus Pyricularia oryzae is Associated With Repressive Histone Modifications.Molecular biology and evolution · 2023Article
- A bacterial-like Pictet-Spenglerase drives the evolution of fungi to produce β-carboline glycosides together with separate genes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genomic Characteristics and Comparative Genomics Analysis ofJournal of fungi (Basel, Switzerland) · 2022Article
- Horizontal Gene Transfer of Triazole Resistance in Aspergillus fumigatus.Microbiology spectrum · 2022Article
- Horizontal transfer and evolution of the biosynthetic gene cluster for benzoxazinoids in plants.Plant communications · 2022Article
- Fungi as mediators linking organisms and ecosystems.FEMS microbiology reviews · 2022Review
41 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFilamentous fungi synthesize many secondary metabolites and are rich in genes encoding proteins involved in their biosynthesis. Genes from the same pathway are often clustered and co-expressed in particular conditions. Such secondary metabolism gene clusters evolve rapidly through multiple rearrangements, duplications and losses. It has long been suspected that clusters can be transferred horizontally between species, but few concrete examples have been described so far.
resultsIn the rice blast fungus Magnaporthe grisea, the avirulence gene ACE1 that codes for a hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) belongs to a cluster of 15 genes involved in secondary metabolism. Additional related clusters were detected in the ascomycetes Chaetomium globosum, Stagonospora nodorum and Aspergillus clavatus. Gene-by-gene phylogenetic analysis showed that in C. globosum and M. grisea, the evolution of these ACE1-like clusters is characterized by successive complex duplication events including tandem duplication within the M. grisea cluster. The phylogenetic trees also present evidence that at least five of the six genes in the homologous ACE1 gene cluster in A. clavatus originated by horizontal transfer from a donor closely related to M. grisea.
conclusionThe ACE1 cluster originally identified in M. grisea is shared by only few fungal species. Its sporadic distribution within euascomycetes is mainly explained by multiple events of duplication and losses. However, because A. clavatus contains an ACE1 cluster of only six genes, we propose that horizontal transfer from a relative of M. grisea into an ancestor of A. clavatus provides a much simpler explanation of the observed data than the alternative of multiple events of duplication and losses of parts of the cluster.
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