ArticleImmunology2008
Expression of langerin/CD207 reveals dendritic cell heterogeneity between inbred mouse strains.
Article in Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo.Antibodies (Basel, Switzerland) · 2022Review
- Additional C-type lectin receptors mediate interactions withJournal of medical microbiology · 2021Article
- Langerhans Cells From Mice at Birth Express Endocytic- and Pattern Recognition-Receptors, Migrate to Draining Lymph Nodes Ferrying Antigen and Activate Neonatal T CellsFrontiers in immunology · 2020Article
- Advancing immunomodulation by in vivo antigen delivery to DEC-205 and other cell surface molecules using recombinant chimeric antibodies.International immunopharmacology · 2019Review
- LangerinFrontiers in immunology · 2019Review
- Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues.Mucosal immunology · 2017Review
- The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b(+)Gr1(+) Cells in a Transgenic Mouse Model.BioMed research international · 2016Article
- Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses.PLoS pathogens · 2015Article
- Dendritic cell-based vaccination in cancer: therapeutic implications emerging from murine models.Frontiers in immunology · 2015Review
- Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance.EMBO molecular medicine · 2014Article
- NKp46 regulates allergic responses.European journal of immunology · 2013Article
- Decorin potentiates interferon-γ activity in a model of allergic inflammation.The Journal of biological chemistry · 2013Article
- Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.Annual review of immunology · 2013Review
- Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice.Journal of dermatological science · 2012Article
- Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains.Respiratory research · 2012Article
- Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Dendritic cell subsets as vectors and targets for improved cancer therapy.Current topics in microbiology and immunology · 2011Review
- In vivo function of Langerhans cells and dermal dendritic cells.Trends in immunology · 2010Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Langerin/CD207 is expressed by a subset of dendritic cells (DC), the epithelial Langerhans cells. However, langerin is also detected among lymphoid tissue DC. Here, we describe striking differences in langerin-expressing cells between inbred mouse strains. While langerin+ cells are observed in comparable numbers and with comparable phenotypes in the epidermis, two distinct DC subsets bear langerin in peripheral, skin-draining lymph nodes of BALB/c mice (CD11c(high) CD8alpha(high) and CD11c(low) CD8alpha(low)), whereas only the latter subset is present in C57BL/6 mice. The CD11c(high) subset is detected in mesenteric lymph nodes and spleen of BALB/c mice, but is virtually absent from C57BL/6 mice. Similar differences are observed in other mouse strains. CD11c(low) langerin+ cells represent skin-derived Langerhans cells, as demonstrated by their high expression of DEC-205/CD205, maturation markers, and recruitment to skin-draining lymph nodes upon imiquimod-induced inflammation. It will be of interest to determine the role of lymphoid tissue-resident compared to skin-derived langerin+ DC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.