ArticleImmunology2008
Effect of SIVmac infection on plasmacytoid and CD1c+ myeloid dendritic cells in cynomolgus macaques.
Article in Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Role of Dendritic Cells in Natural Immune Control of HIV-1 Infection.Frontiers in immunology · 2019Review
- Early SIV and HIV infection promotes the LILRB2/MHC-I inhibitory axis in cDCs.Cellular and molecular life sciences : CMLS · 2018Article
- From dendritic cells to B cells dysfunctions during HIV-1 infection: T follicular helper cells at the crossroads.Immunology · 2017Review
- Type I Interferon Responses by HIV-1 Infection: Association with Disease Progression and Control.Frontiers in immunology · 2017Review
- Effect of chronic morphine administration on circulating dendritic cells in SIV-infected rhesus macaques.Journal of neuroimmunology · 2016Article
- Macrophage accumulation in gut mucosa differentiates AIDS from chronic SIV infection in rhesus macaques.European journal of immunology · 2016Article
- Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques.PLoS pathogens · 2014Article
- Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.Clinical and experimental immunology · 2013Article
- Multi-functional plasmacytoid dendritic cells redistribute to gut tissues during simian immunodeficiency virus infection.Immunology · 2013Article
- Virus-encoded TLR ligands reveal divergent functional responses of mononuclear phagocytes in pathogenic simian immunodeficiency virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Simian immunodeficiency virus interactions with macaque dendritic cells.Advances in experimental medicine and biology · 2013Review
- Review
- Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.Journal of virology · 2012Article
- CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates.European journal of immunology · 2012Article
- Generalized immune activation and innate immune responses in simian immunodeficiency virus infection.Current opinion in HIV and AIDS · 2011Review
- A divergent myeloid dendritic cell response at virus set-point predicts disease outcome in SIV-infected rhesus macaques.Journal of medical primatology · 2011Article
- Article
- Article
- The early interferon alpha subtype response in infant macaques infected orally with SIV.Journal of acquired immune deficiency syndromes (1999) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Dendritic cells (DCs) are known to be essential for the induction and regulation of immune responses. Non-human primates are essential in biomedical research and contribute to our understanding of the involvement of DCs in human infectious diseases. However, no direct single-platform method for quantifying DC precursors has yet been optimized in macaques to give accurate absolute blood counts of these rare-event cell populations in the blood. We adapted a rapid whole-blood assay for the absolute quantification of DCs in cynomolgus macaques by four-colour flow cytometry, using a single-platform assay compatible with human blood. Cynomolgus macaque plasmacytoid DCs (pDCs) and CD1c(+) myeloid DCs (CD1c(+) mDCs) were quantified in the blood of 34 healthy macaques and the results obtained were compared with those for blood samples from 11 healthy humans. In addition, circulating absolute numbers of pDCs were quantified in cynomolgus macaques chronically infected with SIVmac. During infection, pDC counts decreased whereas circulating CD1c(+) mDC counts increased. Information regarding absolute pDC and mDC counts in non-human primates may improve our understanding of the role of these cells in SIV/HIV infection and in other infectious diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.