ArticleJournal of neuro-oncology2008
The two-pore domain potassium channel TASK3 functionally impacts glioma cell death.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Systematic Review of Molecular Targeted Therapies for Adult-Type Diffuse Glioma: An Analysis of Clinical and Laboratory Studies.International journal of molecular sciences · 2023Pooled it
- The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer.International journal of molecular sciences · 2021Review
- pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology.Cancers · 2020Review
- TASK-3 Downregulation Triggers Cellular Senescence and Growth Inhibition in Breast Cancer Cell Lines.International journal of molecular sciences · 2018Article
- A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.Nature communications · 2016Article
- TASK-1 Regulates Apoptosis and Proliferation in a Subset of Non-Small Cell Lung Cancers.PloS one · 2016Article
- The role of ion channels in malignant brain tumors.Journal of neuro-oncology · 2015Review
- Article
- Cl- and K+ channels and their role in primary brain tumour biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Ion channels and transporters in the development of drug resistance in cancer cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Autocrine regulation of glioma cell proliferation via pHe-sensitive K(+) channels.American journal of physiology. Cell physiology · 2014Article
- Enhancement of TWIK-related acid-sensitive potassium channel 3 (TASK3) two-pore domain potassium channel activity by tumor necrosis factor α.The Journal of biological chemistry · 2014Article
- The roles of K(+) channels in cancer.Nature reviews. Cancer · 2014Review
- Involvement of tumor acidification in brain cancer pathophysiology.Frontiers in physiology · 2013Review
- Ion channels as targets for cancer therapy.International journal of physiology, pathophysiology and pharmacology · 2011Article
- From the background to the spotlight: TASK channels in pathological conditions.Brain pathology (Zurich, Switzerland) · 2010Review
- TASK3 and its role in neuro and systemic oncogenesis.Journal of neuro-oncology · 2008Article
- Imprinting evolution and human health.Mammalian genome : official journal of the International Mammalian Genome SocietyReview
- Potential rules of anesthetic gases on glioma.Medical gas researchReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two-pore domain K(+) channels, a recently discovered family of ion channels with a unique membrane topology, have been shown to be critically involved in cell death. We here address the functional role of TASK3 (TWIK-related acid-sensitive K(+) channel, KCNK9) in human glioblastoma in vitro and in vivo. Human glioma cell lines (n = 5) as well as glioma specimens (n = 5) constitutively express TASK3 mRNA and protein. The functional impact of the potassium channel on cell survival was investigated using a medium with high (25 mM) extracellular potassium over 7 days. Using flow cytometric assessment, we show that under these culture conditions 97 +/- 0.76% of all glioma cells survived. Application of the TASK channel opener isoflurane (1 vol%) resulted in a 30 +/- 4% reduction of cell survival in different glioma cell lines. Simultaneous application of isoflurane and the TASK channel blockers bupivacaine (20 microM) and spermine (500 microM) completely reversed this effect. Our results demonstrate the expression of TASK3 in glioma cells in vitro and in vivo and provide a direct link between the TASK3 channel function and glioma cell survival. This implies that TASK3 channels may possibly represent a novel molecular target for the treatment of this type of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.