ArticleMolecular biology of the cell2008
APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
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- Evaluation of Bioaerosol Bacterial Components of a Wastewater Treatment Plant Through an Integrate Approach and In Vivo Assessment.International journal of environmental research and public health · 2019Article
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- Changes in GDPase/UDPase enzymatic activity in response to oxidative stress in four Candida species.Folia microbiologica · 2015Article
- Impact of a Complex Food Microbiota on Energy Metabolism in the Model Organism Caenorhabditis elegans.BioMed research international · 2015Article
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- Developmental diseases caused by impaired nucleotide sugar transporters.Glycoconjugate journal · 2013Review
- Revelation of a catalytic calcium-binding site elucidates unusual metal dependence of a human apyrase.Journal of the American Chemical Society · 2012Article
- Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation.The Journal of biological chemistry · 2012Article
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- Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins.Journal of proteomics · 2011Article
- A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans.Genetics · 2011Article
- The androgen-regulated Calcium-Activated Nucleotidase 1 (CANT1) is commonly overexpressed in prostate cancer and is tumor-biologically relevant in vitro.The American journal of pathology · 2011Article
- Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.Molecular and cellular biology · 2010Article
- Extracellular nucleotides elicit cytosolic free calcium oscillations in Arabidopsis.Plant physiology · 2010Article
- Identification of CANT1 mutations in Desbuquois dysplasia.American journal of human genetics · 2009Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Protein glycosylation modulates a wide variety of intracellular events and dysfunction of the glycosylation pathway has been reported in a variety of human pathologies. Endo-apyrases have been suggested to have critical roles in protein glycosylation and sugar metabolism. However, deciphering the physiological relevance of Endo-apyrases activity has actually proved difficult, owing to their complexity and the functional redundancy within the family. We report here that a UDP/GDPase, homologous to the human apyrase Scan-1, is present in the membranes of Caenorhabditis elegans, encoded by the ORF F08C6.6 and hereinafter-named APY-1. We showed that ER stress induced by tunicamycin or high temperature resulted in increased transcription of apy-1. This increase was not observed in C. elegans mutants defective in ire-1 or atf-6, demonstrating the requirement of both ER stress sensors for up-regulation of apy-1. Depletion of APY-1 resulted in constitutively activated unfolded protein response. Defects in the pharynx and impaired organization of thin fibers in muscle cells were observed in adult worms depleted of APY-1. Some of the apy-1(RNAi) phenotypes are suggestive of premature aging, because these animals also showed accumulation of lipofuscin and reduced lifespan that was not dependent on the functioning of DAF-2, the receptor of the insulin/IGF-1 signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.