ArticleMolecular biology of the cell2008
UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
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Who cites it
158 citing papers in PubMed.
- Two Ume6 target gene classes in the biofilm regulatory network ofbioRxiv : the preprint server for biology · 2026Article
- Candida auris uses nutrient sensing to modulate virulence and host immune responses.Nature microbiology · 2026Article
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- Impact ofmSphere · 2026Article
- A Novel Role of Ume6 inJournal of fungi (Basel, Switzerland) · 2026Article
- Depletion of theMicrobiology (Reading, England) · 2026Article
- A screen to identify antifungal antagonists reveals a variety of pharmacotherapies that induce echinocandin tolerance inAntimicrobial agents and chemotherapy · 2025Article
- Ume6 protein complexes connect morphogenesis, adherence and hypoxic genes to shape Candida albicans biofilm architecture.Nature microbiology · 2025Article
- Coordinated regulation of pH alkalinization by two transcription factors promotes fungal commensalism and pathogenicity.Nature communications · 2025Article
- Article
- Roles of P-body factors inbioRxiv : the preprint server for biology · 2025Article
- Ribosome profiling reveals differences in global translational vs transcriptional gene expression changes during earlyMicrobiology spectrum · 2025Article
- Roles of P-body factors in Candida albicans filamentation and stress response.PLoS genetics · 2025Article
- Adaptation of Candida albicans to specific host environments by gain-of-function mutations in transcription factors.PLoS pathogens · 2024Review
- A single gene mutation underpins metabolic adaptation and acquisition of filamentous competence in the emerging fungal pathogen Candida auris.PLoS pathogens · 2024Article
- Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis.PLoS pathogens · 2024Article
- A chemically induced attenuated strain ofeLife · 2024Article
- Transdermal administration of farnesol-ethosomes enhances the treatment of cutaneous candidiasis induced byMicrobiology spectrum · 2024Article
- The role of themSphere · 2024Article
- Mechanisms of antifungal resistance and developments in alternative strategies to combat Candida albicans infection.Archives of microbiology · 2024Review
98 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
The specific ability of the major human fungal pathogen Candida albicans, as well as many other pathogenic fungi, to extend initial short filaments (germ tubes) into elongated hyphal filaments is important for a variety of virulence-related processes. However, the molecular mechanisms that control hyphal extension have remained poorly understood for many years. We report the identification of a novel C. albicans transcriptional regulator, UME6, which is induced in response to multiple host environmental cues and is specifically important for hyphal extension. Although capable of forming germ tubes, the ume6Delta/ume6Delta mutant exhibits a clear defect in hyphal extension both in vitro and during infection in vivo and is attenuated for virulence in a mouse model of systemic candidiasis. We also show that UME6 is an important downstream component of both the RFG1-TUP1 and NRG1-TUP1 filamentous growth regulatory pathways, and we provide evidence to suggest that Nrg1 and Ume6 function together by a negative feedback loop to control the level and duration of filament-specific gene expression in response to inducing conditions. Our results suggest that hyphal extension is controlled by a specific transcriptional regulatory mechanism and is correlated with the maintenance of high-level expression of genes in the C. albicans filamentous growth program.
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