ArticleProceedings of the National Academy of Sciences of the United States of America2008
Preferential protection of protein interaction network hubs in yeast: evolved functionality of genetic redundancy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- The aging genome exhibits organized vulnerability to somatic mutations.bioRxiv : the preprint server for biology · 2026Article
- Essentiality and dynamic expression of the human tRNA pool during viral infection.Molecular systems biology · 2026Article
- Active compensation for changes in TDH3 expression mediated by direct regulators of TDH3 in Saccharomyces cerevisiae.PLoS genetics · 2023Article
- Evolutionary conservation of sequence motifs at sites of protein modification.The Journal of biological chemistry · 2023Article
- Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response.Genetics · 2023Article
- A rice protein interaction network reveals high centrality nodes and candidate pathogen effector targets.Computational and structural biotechnology journal · 2022Article
- A computational exploration of resilience and evolvability of protein-protein interaction networks.Communications biology · 2021Article
- Molecular signatures of silencing suppression degeneracy from a complex RNA virus.PLoS computational biology · 2021Article
- Degree of Functional Divergence in Duplicates Is Associated with Distinct Roles in Plant Evolution.Molecular biology and evolution · 2021Article
- Connecting the αα-hubs: same fold, disordered ligands, new functions.Cell communication and signaling : CCS · 2021Article
- Review
- Duplication history and molecular evolution of the rbcS multigene family in angiosperms.Journal of experimental botany · 2019Article
- Network biology discovers pathogen contact points in host protein-protein interactomes.Nature communications · 2018Article
- Role of duplicate genes in determining the tissue-selectivity of hereditary diseases.PLoS genetics · 2018Article
- Building protein-protein interaction networks for Leishmania species through protein structural information.BMC bioinformatics · 2018Article
- Systems-level analysis of human aging genes shed new light on mechanisms of aging.Human molecular genetics · 2016Article
- Binding interface change and cryptic variation in the evolution of protein-protein interactions.BMC evolutionary biology · 2016Article
- Expression of Agrobacterium Homolog Genes Encoding T-complex Recruiting Protein under Virulence Induction Conditions.Frontiers in microbiology · 2015Article
- Expression evolution facilitated the convergent neofunctionalization of a sodium channel gene.Molecular biology and evolution · 2014Article
- Ancient gene duplicates in Gossypium (cotton) exhibit near-complete expression divergence.Genome biology and evolution · 2014Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The widely observed dispensability of duplicate genes is typically interpreted to suggest that a proportion of the duplicate pairs are at least partially redundant in their functions, thus allowing for compensatory affects. However, because redundancy is expected to be evolutionarily short lived, there is currently debate on both the proportion of redundant duplicates and their functional importance. Here, we examined these compensatory interactions by relying on a genome wide data analysis, followed by experiments and literature mining in yeast. Our data, thus, strongly suggest that compensated duplicates are not randomly distributed within the protein interaction network but are rather strategically allocated to the most highly connected proteins. This design is appealing because it suggests that many of the potentially vulnerable nodes that would otherwise be highly sensitive to mutations are often protected by redundancy. Furthermore, divergence analyses show that this association between redundancy and protein connectivity becomes even more significant among the ancient duplicates, suggesting that these functional overlaps have undergone purifying selection. Our results suggest an intriguing conclusion-although redundancy is typically transient on evolutionary time scales, it tends to be preserved among some of the central proteins in the cellular interaction network.
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