ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Parallel processing of nociceptive A-delta inputs in SII and midcingulate cortex in humans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.
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- The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Pooled it
- Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab.The journal of headache and pain · 2022Trial
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- How the Brain Interprets Pain in Autistic People: Does Sex Matter?European journal of pain (London, England) · 2026Article
- Modulation of multisensory nociceptive neurons in monkey cortical area 7b and behavioral correlates.Journal of neurophysiology · 2024Article
- Coordination between midcingulate cortex and retrosplenial cortex in pain regulation.Frontiers in molecular neuroscience · 2024Article
- Tinnitus and the Triple Network Model: A Perspective.Clinical and experimental otorhinolaryngology · 2022Review
- Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine.Journal of translational medicine · 2021Article
- Abnormal Intrinsic Functional Interactions Within Pain Network in Cervical Discogenic Pain.Frontiers in neuroscience · 2021Article
- Supraspinal Mechanisms Underlying Ocular Pain.Frontiers in medicine · 2021Review
- The Modular Organization of Pain Brain Networks: An fMRI Graph Analysis Informed by Intracranial EEG.Cerebral cortex communications · 2020Article
- Foreword.Pain medicine (Malden, Mass.) · 2019Article
- Acupuncture for Histamine-Induced Itch: Association With Increased Parasympathetic Tone and Connectivity of Putamen-Midcingulate Cortex.Frontiers in neuroscience · 2019Article
- Abnormal Circadian Modification of APain research & management · 2019Article
- Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli.Nature communications · 2018Article
- [Pain and epilepsy : A clinical, neuroanatomical and pathophysiological review].Schmerz (Berlin, Germany) · 2018Article
- Designing Brains for Pain: Human to Mollusc.Frontiers in physiology · 2018Article
- Evidence-based source modeling of nociceptive cortical responses: A direct comparison of scalp and intracranial activity in humans.Human brain mapping · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cingulate cortex (CC) as a part of the "medial" pain subsystem is generally assumed to be involved in the affective and/or cognitive dimensions of pain processing, which are viewed as relatively slow processes compared with the sensory-discriminative pain coding by the lateral second somatosensory area (SII)-insular cortex. The present study aimed at characterizing the location and timing of the CC evoked responses during the 1 s period after a painful laser stimulus, by exploring the whole rostrocaudal extent of this cortical area using intracortical recordings in humans. Only a restricted area in the median CC region responded to painful stimulation, namely the posterior midcingulate cortex (pMCC), the location of which is consistent with the so-called "motor CC" in monkeys. Cingulate pain responses showed two components, of which the earliest peaked at latencies similar to those obtained in SII. These data provide direct evidence that activations underlying the processing of nociceptive information can occur simultaneously in the "medial" and "lateral" subsystems. The existence of short-latency pMCC responses to pain further indicates that the "medial pain system" is not devoted exclusively to the processing of emotional information, but is also involved in fast attentional orienting and motor withdrawal responses to pain inputs. These functions are, not surprisingly, conducted in parallel with pain intensity coding and stimulus localization specifically subserved by the sensory-discriminative "lateral" pain system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.