ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Homosynaptic long-term synaptic potentiation of the "winner" climbing fiber synapse in developing Purkinje cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Competitive Olivocerebellar Input Selection Promotes Resilient Circuit Formation.bioRxiv : the preprint server for biology · 2026Article
- mGluR1 signaling is necessary for strengthening winner climbing fiber inputs in the developing mouse cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Eye-specific differences in active zone addition during synaptic competition in the developing visual system.bioRxiv : the preprint server for biology · 2025Article
- Synaptic transmission is dispensable for selecting the winner input but is crucial for the subsequent events of synapse elimination.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Molecular and Anatomical Strengthening of "Winner" Climbing Fiber Synapses in Developing Mouse Purkinje Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cerebellar control of targeted tongue movements.The Journal of physiology · 2025Article
- Tools foreNeuro · 2024Article
- Viral-mediated inflammation by Poly I:C induces the chemokine CCL5 in NK cells and its receptors CCR1 and CCR5 in microglia in the neonatal rat cerebellum.NeuroImmune pharmacology and therapeutics · 2024Article
- Tools forbioRxiv : the preprint server for biology · 2024Article
- Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human.Science (New York, N.Y.) · 2023Article
- Gating by Functionally Indivisible Cerebellar Circuits: a Hypothesis.Cerebellum (London, England) · 2021Article
- Structure-function relation of the developing calyx of Held synapse in vivo.The Journal of physiology · 2020Article
- Developmental Rewiring between Cerebellar Climbing Fibers and Purkinje Cells Begins with Positive Feedback Synapse Addition.Cell reports · 2019Article
- AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise.Neurochemical research · 2019Review
- Roles for neuronal and glial autophagy in synaptic pruning during development.Neurobiology of disease · 2019Review
- Developmental Easing of Short-Term Depression in "Winner" Climbing Fibers.Frontiers in cellular neuroscience · 2019Article
- Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.Cerebellum (London, England) · 2018Review
- Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.Cell reports · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the developmental formation of neuronal circuits, redundant synapses are eliminated and persisting synapses strengthened. In the immature cerebellum, climbing fiber-Purkinje cell synapses undergo a pronounced synaptic rewiring, from a multiple innervation around birth to a mono-innervation in adults. An early stage of this process consists in the differentiation of initially equally strong synapses into one "large" and several "small" synaptic inputs. By performing whole-cell recordings in Purkinje cells of rat cerebellar slices, we found that the coincident activation of a Purkinje cell and one of its afferent climbing fibers induces homosynaptic long-term synaptic potentiation (LTP). This LTP requires postsynaptic Ca2+ signaling and involves an increase in the single channel conductance of the postsynaptic AMPA receptors. Interestingly, LTP occurs exclusively at large synaptic inputs. It is not observed at small inputs that are eventually eliminated. Thus, we identified a new form of LTP that is expressed uniquely and just for a restricted period of early development in the large climbing fiber inputs. Our results suggest that this LTP mediates the activity-dependent maturation of the "winner" climbing fiber.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.