Evidence map›Paper›PMID 18216123›Full record

ArticleJournal of virology2008

Novel mammalian herpesviruses and lineages within the Gammaherpesvirinae: cospeciation and interspecies transfer.

Bernhard Ehlers, Güzin Dural, Nezlisah Yasmum, Tiziana Lembo, Benoit de Thoisy, Marie-Pierre Ryser-Degiorgis, Rainer G Ulrich, Duncan J McGeoch

Abstract read
In one paragraph

Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 131 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Tissue and cellular tropism ofVeterinary pathology · 2024
    Article
  9. Article
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  13. Article
  14. Molecular survey of selected viruses in Pudus (The veterinary quarterly · 2023
    Article
  15. Detection of herpesviruses in neotropical primates from São Paulo, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Bernhard EhlersP14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch-Institut, D-13353 Berlin, Germany. ehlersb@rki.de
Güzin Dural
Nezlisah Yasmum
Tiziana Lembo
Benoit de Thoisy
Marie-Pierre Ryser-Degiorgis
Rainer G Ulrich
Duncan J McGeoch
Robert Koch Institute · DEFriedrich-Loeffler-Institut · DEInstitut Pasteur de la Guyane · GFUniversity of Bern · CHUniversity of Edinburgh · GBUniversity of Glasgow · GB

Funding

Medical Research Council MC_U130169960
6 · The paper itself

Abstract

Novel members of the subfamily Gammaherpesvirinae, hosted by eight mammalian species from six orders (Primates, Artiodactyla, Perissodactyla, Carnivora, Scandentia, and Eulipotyphla), were discovered using PCR with pan-herpesvirus DNA polymerase (DPOL) gene primers and genus-specific glycoprotein B (gB) gene primers. The gB and DPOL sequences of each virus species were connected by long-distance PCR, and contiguous sequences of approximately 3.4 kbp were compiled. Six additional gammaherpesviruses from four mammalian host orders (Artiodactyla, Perissodactyla, Primates, and Proboscidea), for which only short DPOL sequences were known, were analyzed in the same manner. Together with available corresponding sequences for 31 other gammaherpesviruses, alignments of encoded amino acid sequences were made and used for phylogenetic analyses by maximum-likelihood and Bayesian Monte Carlo Markov chain methods to derive a tree which contained two major loci of unresolved branching details. The tree was rooted by parallel analyses that included alpha- and betaherpesvirus sequences. This gammaherpesvirus tree contains 11 major lineages and presents the widest view to date of phylogenetic relationships in any subfamily of the Herpesviridae, as well as the most complex in the number of deep lineages. The tree's branching pattern can be interpreted only in part in terms of the cospeciation of virus and host lineages, and a substantial incidence of the interspecies transfer of viruses must also be invoked.

Indexed as

AnimalsCluster AnalysisDNA Polymerase IIIDNA PrimersDNA, ViralGammaherpesvirinaeHumansMammalsMolecular Sequence DataPhylogenyPolymerase Chain ReactionSequence Analysis, DNASequence HomologyViral Structural ProteinsDNA polymerase ADNA Polymerase IIIDNA PrimersDNA, ViralViral Structural Proteins

Identifiers

PMID18216123
PMCPMC2268488
OpenAlexW2130030698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.